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Zona pellucida shear modulus, a possible novel non-invasive method to assist in embryo selection during in-vitro fertilization treatment

The present study investigated the association between oocyte zona pellucida shear modulus (ZPSM) and implantation rate (IR). Ninety-three oocytes collected from 38 in-vitro fertilization patients who underwent intracytoplasmic sperm injection were included in this case–control study. The ZP was mod...

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Autores principales: Priel, Elad, Priel, Tsvia, Szaingurten-Solodkin, Irit, Wainstock, Tamar, Perets, Yuval, Zeadna, Atif, Harlev, Avi, Lunenfeld, Eitan, Levitas, Eliahu, Har-Vardi, Iris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443135/
https://www.ncbi.nlm.nih.gov/pubmed/32826934
http://dx.doi.org/10.1038/s41598-020-70739-y
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author Priel, Elad
Priel, Tsvia
Szaingurten-Solodkin, Irit
Wainstock, Tamar
Perets, Yuval
Zeadna, Atif
Harlev, Avi
Lunenfeld, Eitan
Levitas, Eliahu
Har-Vardi, Iris
author_facet Priel, Elad
Priel, Tsvia
Szaingurten-Solodkin, Irit
Wainstock, Tamar
Perets, Yuval
Zeadna, Atif
Harlev, Avi
Lunenfeld, Eitan
Levitas, Eliahu
Har-Vardi, Iris
author_sort Priel, Elad
collection PubMed
description The present study investigated the association between oocyte zona pellucida shear modulus (ZPSM) and implantation rate (IR). Ninety-three oocytes collected from 38 in-vitro fertilization patients who underwent intracytoplasmic sperm injection were included in this case–control study. The ZP was modeled as an isotropic compressible hyperelastic material with parameter [Formula: see text] , which represents the ZPSM. Computational methodology was used to calculate the mechanical parameters that govern ZP deformation. Fifty-one developed embryos were transferred and divided into two groups—implanted and not implanted. Multivariate logistic regression analysis was performed to identify the association between ZPSM and IR while controlling for confounders. Maternal age and number of embryos per transfer were significantly associated with implantation. The IR of embryos characterized by [Formula: see text] values in the range of 0.20–0.40 kPa was 66.75%, while outside this range it was 6.70%. This range was significantly associated with implantation (p < 0.001). Geometric properties were not associated with implantation. Multivariate logistic regression analysis that controlled for relevant confounders indicated that this range was independently associated with implantation (adjusted OR 38.03, 95% confidence interval 4.67–309.36, p = 0.001). The present study suggests that ZPSM may improve the classic embryo selection process with the aim of increasing IR.
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spelling pubmed-74431352020-08-26 Zona pellucida shear modulus, a possible novel non-invasive method to assist in embryo selection during in-vitro fertilization treatment Priel, Elad Priel, Tsvia Szaingurten-Solodkin, Irit Wainstock, Tamar Perets, Yuval Zeadna, Atif Harlev, Avi Lunenfeld, Eitan Levitas, Eliahu Har-Vardi, Iris Sci Rep Article The present study investigated the association between oocyte zona pellucida shear modulus (ZPSM) and implantation rate (IR). Ninety-three oocytes collected from 38 in-vitro fertilization patients who underwent intracytoplasmic sperm injection were included in this case–control study. The ZP was modeled as an isotropic compressible hyperelastic material with parameter [Formula: see text] , which represents the ZPSM. Computational methodology was used to calculate the mechanical parameters that govern ZP deformation. Fifty-one developed embryos were transferred and divided into two groups—implanted and not implanted. Multivariate logistic regression analysis was performed to identify the association between ZPSM and IR while controlling for confounders. Maternal age and number of embryos per transfer were significantly associated with implantation. The IR of embryos characterized by [Formula: see text] values in the range of 0.20–0.40 kPa was 66.75%, while outside this range it was 6.70%. This range was significantly associated with implantation (p < 0.001). Geometric properties were not associated with implantation. Multivariate logistic regression analysis that controlled for relevant confounders indicated that this range was independently associated with implantation (adjusted OR 38.03, 95% confidence interval 4.67–309.36, p = 0.001). The present study suggests that ZPSM may improve the classic embryo selection process with the aim of increasing IR. Nature Publishing Group UK 2020-08-21 /pmc/articles/PMC7443135/ /pubmed/32826934 http://dx.doi.org/10.1038/s41598-020-70739-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Priel, Elad
Priel, Tsvia
Szaingurten-Solodkin, Irit
Wainstock, Tamar
Perets, Yuval
Zeadna, Atif
Harlev, Avi
Lunenfeld, Eitan
Levitas, Eliahu
Har-Vardi, Iris
Zona pellucida shear modulus, a possible novel non-invasive method to assist in embryo selection during in-vitro fertilization treatment
title Zona pellucida shear modulus, a possible novel non-invasive method to assist in embryo selection during in-vitro fertilization treatment
title_full Zona pellucida shear modulus, a possible novel non-invasive method to assist in embryo selection during in-vitro fertilization treatment
title_fullStr Zona pellucida shear modulus, a possible novel non-invasive method to assist in embryo selection during in-vitro fertilization treatment
title_full_unstemmed Zona pellucida shear modulus, a possible novel non-invasive method to assist in embryo selection during in-vitro fertilization treatment
title_short Zona pellucida shear modulus, a possible novel non-invasive method to assist in embryo selection during in-vitro fertilization treatment
title_sort zona pellucida shear modulus, a possible novel non-invasive method to assist in embryo selection during in-vitro fertilization treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443135/
https://www.ncbi.nlm.nih.gov/pubmed/32826934
http://dx.doi.org/10.1038/s41598-020-70739-y
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