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IKBKB rs2272736 is Associated with Gastric Cancer Survival
BACKGROUND: IKBKB/IKKβ, as the core catalytic subunit of IκB kinase complex, participates in mediation of the classical NF-κB pathway, which has been linked to inflammation and tumorigenesis. Previous studies have shown that single nucleotide polymorphisms in IKBKB have been related to gastric cance...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443400/ https://www.ncbi.nlm.nih.gov/pubmed/32884329 http://dx.doi.org/10.2147/PGPM.S258761 |
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author | Gong, Yang Zhao, Wenjing Jia, Qiong Dai, Jiali Chen, Nan Chen, Yuetong Gu, Dongying Huo, Xinying Chen, Jinfei |
author_facet | Gong, Yang Zhao, Wenjing Jia, Qiong Dai, Jiali Chen, Nan Chen, Yuetong Gu, Dongying Huo, Xinying Chen, Jinfei |
author_sort | Gong, Yang |
collection | PubMed |
description | BACKGROUND: IKBKB/IKKβ, as the core catalytic subunit of IκB kinase complex, participates in mediation of the classical NF-κB pathway, which has been linked to inflammation and tumorigenesis. Previous studies have shown that single nucleotide polymorphisms in IKBKB have been related to gastric cancer, but how they associate to the clinical outcome is not yet clear. In this study, we retrospectively investigated the associations between single nucleotide polymorphisms located in IKBKB and gastric cancer survival. MATERIALS AND METHODS: IKBKB rs2272736 was genotyped in 1210 patients with primary gastric cancer in a Han Chinese population, and the relationships between rs2272736 and overall survival were evaluated. We conducted Cox proportional hazards regression, which was performed to estimate the effects of single nucleotide polymorphisms on the overall survival of patients, adjusted for potential confounding variables. RESULTS: We found that patients with rs2272736 A allele in IKBKB had significantly prolonged overall survival time compared to those with the G allele (HR = 0.83, 95% CI = 0.68–1.00, P = 0.050). In addition, AA genotype was demonstrated to have reduced risk of death for gastric cancer compared with that associated with the GG/GA genotypes, which was more common in patients with cardiac carcinoma, well-differentiated and moderately differentiated tumors, TNM Ⅰ/Ⅱ stages and intestinal type. CONCLUSION: Our findings have shown that single nucleotide polymorphism rs2272736 in IKBKB may be a promising prognostic biomarker which should promote personalized treatment. |
format | Online Article Text |
id | pubmed-7443400 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-74434002020-09-02 IKBKB rs2272736 is Associated with Gastric Cancer Survival Gong, Yang Zhao, Wenjing Jia, Qiong Dai, Jiali Chen, Nan Chen, Yuetong Gu, Dongying Huo, Xinying Chen, Jinfei Pharmgenomics Pers Med Original Research BACKGROUND: IKBKB/IKKβ, as the core catalytic subunit of IκB kinase complex, participates in mediation of the classical NF-κB pathway, which has been linked to inflammation and tumorigenesis. Previous studies have shown that single nucleotide polymorphisms in IKBKB have been related to gastric cancer, but how they associate to the clinical outcome is not yet clear. In this study, we retrospectively investigated the associations between single nucleotide polymorphisms located in IKBKB and gastric cancer survival. MATERIALS AND METHODS: IKBKB rs2272736 was genotyped in 1210 patients with primary gastric cancer in a Han Chinese population, and the relationships between rs2272736 and overall survival were evaluated. We conducted Cox proportional hazards regression, which was performed to estimate the effects of single nucleotide polymorphisms on the overall survival of patients, adjusted for potential confounding variables. RESULTS: We found that patients with rs2272736 A allele in IKBKB had significantly prolonged overall survival time compared to those with the G allele (HR = 0.83, 95% CI = 0.68–1.00, P = 0.050). In addition, AA genotype was demonstrated to have reduced risk of death for gastric cancer compared with that associated with the GG/GA genotypes, which was more common in patients with cardiac carcinoma, well-differentiated and moderately differentiated tumors, TNM Ⅰ/Ⅱ stages and intestinal type. CONCLUSION: Our findings have shown that single nucleotide polymorphism rs2272736 in IKBKB may be a promising prognostic biomarker which should promote personalized treatment. Dove 2020-08-19 /pmc/articles/PMC7443400/ /pubmed/32884329 http://dx.doi.org/10.2147/PGPM.S258761 Text en © 2020 Gong et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Gong, Yang Zhao, Wenjing Jia, Qiong Dai, Jiali Chen, Nan Chen, Yuetong Gu, Dongying Huo, Xinying Chen, Jinfei IKBKB rs2272736 is Associated with Gastric Cancer Survival |
title | IKBKB rs2272736 is Associated with Gastric Cancer Survival |
title_full | IKBKB rs2272736 is Associated with Gastric Cancer Survival |
title_fullStr | IKBKB rs2272736 is Associated with Gastric Cancer Survival |
title_full_unstemmed | IKBKB rs2272736 is Associated with Gastric Cancer Survival |
title_short | IKBKB rs2272736 is Associated with Gastric Cancer Survival |
title_sort | ikbkb rs2272736 is associated with gastric cancer survival |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443400/ https://www.ncbi.nlm.nih.gov/pubmed/32884329 http://dx.doi.org/10.2147/PGPM.S258761 |
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