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Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China

BACKGROUND: Obesity is reported to be associated with oxidative stress which can cause lipid peroxidation. However, the effects of gain in various weight-related anthropometric indices on lipid peroxidation remain unclear. We aimed to examine the cross-sectional and longitudinal associations between...

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Autores principales: Xu, Tao, Wang, Bin, Cao, Limin, Qiu, Weihong, Zhang, Zhuang, Chen, Ailian, Chen, Weihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443444/
https://www.ncbi.nlm.nih.gov/pubmed/32884314
http://dx.doi.org/10.2147/DMSO.S259194
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author Xu, Tao
Wang, Bin
Cao, Limin
Qiu, Weihong
Zhang, Zhuang
Chen, Ailian
Chen, Weihong
author_facet Xu, Tao
Wang, Bin
Cao, Limin
Qiu, Weihong
Zhang, Zhuang
Chen, Ailian
Chen, Weihong
author_sort Xu, Tao
collection PubMed
description BACKGROUND: Obesity is reported to be associated with oxidative stress which can cause lipid peroxidation. However, the effects of gain in various weight-related anthropometric indices on lipid peroxidation remain unclear. We aimed to examine the cross-sectional and longitudinal associations between altered weight-related anthropometric indices and a marker of lipid peroxidation among urban adults in China. METHODS: A total of 3762 participants from the Wuhan-Zhuhai cohort were included in the present study, with a follow-up of 3 years. Six weight-related anthropometric indicators were measured and calculated, including waist circumference (WC), body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), a body shape index (ABSI), and body adiposity index (BAI). Individual urinary 8-iso-prostaglandin-F(2α) (8-iso-PGF(2α)) was determined via enzyme-linked immunosorbent assay to evaluate lipid peroxidation. We used generalized linear models to analyze the cross-sectional and longitudinal associations of weight-related anthropometric indices with a marker of lipid peroxidation and stratified analyses to estimate effect modification. RESULTS: We found significant relationships between WHR, WHtR, ABSI, and urinary 8-iso-PGF(2α) at baseline. Each 1% increase in WHR, WHtR, and ABSI was significantly associated with a 0.007, 0.004, and 0.104 increase in log-transformed 8-iso-PGF(2α) concentration, respectively (P<0.05). In longitudinal analysis, positive dose–response relationships were observed between gains in BMI, BAI, and increased 8-iso-PGF(2α) after adjusting for potential confounders (P(trend)<0.05). We also found that gender and smoking status modified the association of BMI gain and 8-iso-PGF(2α) increment, and such an association was more obvious in female and non-smokers. CONCLUSION: Our research implied that gain in anthropometric indices may result in a higher level of lipid peroxidation.
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spelling pubmed-74434442020-09-02 Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China Xu, Tao Wang, Bin Cao, Limin Qiu, Weihong Zhang, Zhuang Chen, Ailian Chen, Weihong Diabetes Metab Syndr Obes Original Research BACKGROUND: Obesity is reported to be associated with oxidative stress which can cause lipid peroxidation. However, the effects of gain in various weight-related anthropometric indices on lipid peroxidation remain unclear. We aimed to examine the cross-sectional and longitudinal associations between altered weight-related anthropometric indices and a marker of lipid peroxidation among urban adults in China. METHODS: A total of 3762 participants from the Wuhan-Zhuhai cohort were included in the present study, with a follow-up of 3 years. Six weight-related anthropometric indicators were measured and calculated, including waist circumference (WC), body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), a body shape index (ABSI), and body adiposity index (BAI). Individual urinary 8-iso-prostaglandin-F(2α) (8-iso-PGF(2α)) was determined via enzyme-linked immunosorbent assay to evaluate lipid peroxidation. We used generalized linear models to analyze the cross-sectional and longitudinal associations of weight-related anthropometric indices with a marker of lipid peroxidation and stratified analyses to estimate effect modification. RESULTS: We found significant relationships between WHR, WHtR, ABSI, and urinary 8-iso-PGF(2α) at baseline. Each 1% increase in WHR, WHtR, and ABSI was significantly associated with a 0.007, 0.004, and 0.104 increase in log-transformed 8-iso-PGF(2α) concentration, respectively (P<0.05). In longitudinal analysis, positive dose–response relationships were observed between gains in BMI, BAI, and increased 8-iso-PGF(2α) after adjusting for potential confounders (P(trend)<0.05). We also found that gender and smoking status modified the association of BMI gain and 8-iso-PGF(2α) increment, and such an association was more obvious in female and non-smokers. CONCLUSION: Our research implied that gain in anthropometric indices may result in a higher level of lipid peroxidation. Dove 2020-08-18 /pmc/articles/PMC7443444/ /pubmed/32884314 http://dx.doi.org/10.2147/DMSO.S259194 Text en © 2020 Xu et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Xu, Tao
Wang, Bin
Cao, Limin
Qiu, Weihong
Zhang, Zhuang
Chen, Ailian
Chen, Weihong
Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China
title Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China
title_full Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China
title_fullStr Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China
title_full_unstemmed Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China
title_short Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China
title_sort associations of gain in weight-related anthropometric indices with a marker of lipid peroxidation: a cohort study among urban adults in china
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443444/
https://www.ncbi.nlm.nih.gov/pubmed/32884314
http://dx.doi.org/10.2147/DMSO.S259194
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