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Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China
BACKGROUND: Obesity is reported to be associated with oxidative stress which can cause lipid peroxidation. However, the effects of gain in various weight-related anthropometric indices on lipid peroxidation remain unclear. We aimed to examine the cross-sectional and longitudinal associations between...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443444/ https://www.ncbi.nlm.nih.gov/pubmed/32884314 http://dx.doi.org/10.2147/DMSO.S259194 |
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author | Xu, Tao Wang, Bin Cao, Limin Qiu, Weihong Zhang, Zhuang Chen, Ailian Chen, Weihong |
author_facet | Xu, Tao Wang, Bin Cao, Limin Qiu, Weihong Zhang, Zhuang Chen, Ailian Chen, Weihong |
author_sort | Xu, Tao |
collection | PubMed |
description | BACKGROUND: Obesity is reported to be associated with oxidative stress which can cause lipid peroxidation. However, the effects of gain in various weight-related anthropometric indices on lipid peroxidation remain unclear. We aimed to examine the cross-sectional and longitudinal associations between altered weight-related anthropometric indices and a marker of lipid peroxidation among urban adults in China. METHODS: A total of 3762 participants from the Wuhan-Zhuhai cohort were included in the present study, with a follow-up of 3 years. Six weight-related anthropometric indicators were measured and calculated, including waist circumference (WC), body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), a body shape index (ABSI), and body adiposity index (BAI). Individual urinary 8-iso-prostaglandin-F(2α) (8-iso-PGF(2α)) was determined via enzyme-linked immunosorbent assay to evaluate lipid peroxidation. We used generalized linear models to analyze the cross-sectional and longitudinal associations of weight-related anthropometric indices with a marker of lipid peroxidation and stratified analyses to estimate effect modification. RESULTS: We found significant relationships between WHR, WHtR, ABSI, and urinary 8-iso-PGF(2α) at baseline. Each 1% increase in WHR, WHtR, and ABSI was significantly associated with a 0.007, 0.004, and 0.104 increase in log-transformed 8-iso-PGF(2α) concentration, respectively (P<0.05). In longitudinal analysis, positive dose–response relationships were observed between gains in BMI, BAI, and increased 8-iso-PGF(2α) after adjusting for potential confounders (P(trend)<0.05). We also found that gender and smoking status modified the association of BMI gain and 8-iso-PGF(2α) increment, and such an association was more obvious in female and non-smokers. CONCLUSION: Our research implied that gain in anthropometric indices may result in a higher level of lipid peroxidation. |
format | Online Article Text |
id | pubmed-7443444 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-74434442020-09-02 Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China Xu, Tao Wang, Bin Cao, Limin Qiu, Weihong Zhang, Zhuang Chen, Ailian Chen, Weihong Diabetes Metab Syndr Obes Original Research BACKGROUND: Obesity is reported to be associated with oxidative stress which can cause lipid peroxidation. However, the effects of gain in various weight-related anthropometric indices on lipid peroxidation remain unclear. We aimed to examine the cross-sectional and longitudinal associations between altered weight-related anthropometric indices and a marker of lipid peroxidation among urban adults in China. METHODS: A total of 3762 participants from the Wuhan-Zhuhai cohort were included in the present study, with a follow-up of 3 years. Six weight-related anthropometric indicators were measured and calculated, including waist circumference (WC), body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), a body shape index (ABSI), and body adiposity index (BAI). Individual urinary 8-iso-prostaglandin-F(2α) (8-iso-PGF(2α)) was determined via enzyme-linked immunosorbent assay to evaluate lipid peroxidation. We used generalized linear models to analyze the cross-sectional and longitudinal associations of weight-related anthropometric indices with a marker of lipid peroxidation and stratified analyses to estimate effect modification. RESULTS: We found significant relationships between WHR, WHtR, ABSI, and urinary 8-iso-PGF(2α) at baseline. Each 1% increase in WHR, WHtR, and ABSI was significantly associated with a 0.007, 0.004, and 0.104 increase in log-transformed 8-iso-PGF(2α) concentration, respectively (P<0.05). In longitudinal analysis, positive dose–response relationships were observed between gains in BMI, BAI, and increased 8-iso-PGF(2α) after adjusting for potential confounders (P(trend)<0.05). We also found that gender and smoking status modified the association of BMI gain and 8-iso-PGF(2α) increment, and such an association was more obvious in female and non-smokers. CONCLUSION: Our research implied that gain in anthropometric indices may result in a higher level of lipid peroxidation. Dove 2020-08-18 /pmc/articles/PMC7443444/ /pubmed/32884314 http://dx.doi.org/10.2147/DMSO.S259194 Text en © 2020 Xu et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Xu, Tao Wang, Bin Cao, Limin Qiu, Weihong Zhang, Zhuang Chen, Ailian Chen, Weihong Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China |
title | Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China |
title_full | Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China |
title_fullStr | Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China |
title_full_unstemmed | Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China |
title_short | Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China |
title_sort | associations of gain in weight-related anthropometric indices with a marker of lipid peroxidation: a cohort study among urban adults in china |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443444/ https://www.ncbi.nlm.nih.gov/pubmed/32884314 http://dx.doi.org/10.2147/DMSO.S259194 |
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