HMGB1 in inflammation and cancer

High mobility group box 1 (HMGB1) is a non-histone chromatin-associated protein widely distributed in eukaryotic cells and is involved in DNA damage repair and genomic stability maintenance. In response to stimulus like bacteria or chemoradiotherapy, HMGB1 can translocate to extracellular context as...

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Detalles Bibliográficos
Autores principales: Wang, Shumin, Zhang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443612/
https://www.ncbi.nlm.nih.gov/pubmed/32831115
http://dx.doi.org/10.1186/s13045-020-00950-x
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author Wang, Shumin
Zhang, Yi
author_facet Wang, Shumin
Zhang, Yi
author_sort Wang, Shumin
collection PubMed
description High mobility group box 1 (HMGB1) is a non-histone chromatin-associated protein widely distributed in eukaryotic cells and is involved in DNA damage repair and genomic stability maintenance. In response to stimulus like bacteria or chemoradiotherapy, HMGB1 can translocate to extracellular context as a danger alarmin, activate the immune response, and participate in the regulation of inflammation and cancer progression.
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spelling pubmed-74436122020-08-24 HMGB1 in inflammation and cancer Wang, Shumin Zhang, Yi J Hematol Oncol Editorial High mobility group box 1 (HMGB1) is a non-histone chromatin-associated protein widely distributed in eukaryotic cells and is involved in DNA damage repair and genomic stability maintenance. In response to stimulus like bacteria or chemoradiotherapy, HMGB1 can translocate to extracellular context as a danger alarmin, activate the immune response, and participate in the regulation of inflammation and cancer progression. BioMed Central 2020-08-24 /pmc/articles/PMC7443612/ /pubmed/32831115 http://dx.doi.org/10.1186/s13045-020-00950-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Editorial
Wang, Shumin
Zhang, Yi
HMGB1 in inflammation and cancer
title HMGB1 in inflammation and cancer
title_full HMGB1 in inflammation and cancer
title_fullStr HMGB1 in inflammation and cancer
title_full_unstemmed HMGB1 in inflammation and cancer
title_short HMGB1 in inflammation and cancer
title_sort hmgb1 in inflammation and cancer
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443612/
https://www.ncbi.nlm.nih.gov/pubmed/32831115
http://dx.doi.org/10.1186/s13045-020-00950-x
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