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Specific Hippocampal Interneurons Shape Consolidation of Recognition Memory

A complex array of inhibitory interneurons tightly controls hippocampal activity, but how such diversity specifically affects memory processes is not well understood. We find that a small subclass of type 1 cannabinoid receptor (CB(1)R)-expressing hippocampal interneurons determines episodic-like me...

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Detalles Bibliográficos
Autores principales: Oliveira da Cruz, Jose F., Busquets-Garcia, Arnau, Zhao, Zhe, Varilh, Marjorie, Lavanco, Gianluca, Bellocchio, Luigi, Robin, Laurie, Cannich, Astrid, Julio-Kalajzić, Francisca, Lesté-Lasserre, Thierry, Maître, Marlène, Drago, Filippo, Marsicano, Giovanni, Soria-Gómez, Edgar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443618/
https://www.ncbi.nlm.nih.gov/pubmed/32814049
http://dx.doi.org/10.1016/j.celrep.2020.108046
Descripción
Sumario:A complex array of inhibitory interneurons tightly controls hippocampal activity, but how such diversity specifically affects memory processes is not well understood. We find that a small subclass of type 1 cannabinoid receptor (CB(1)R)-expressing hippocampal interneurons determines episodic-like memory consolidation by linking dopamine D(1) receptor (D(1)R) signaling to GABAergic transmission. Mice lacking CB(1)Rs in D(1)-positive cells (D(1)-CB(1)-KO) display impairment in long-term, but not short-term, novel object recognition memory (NOR). Re-expression of CB(1)Rs in hippocampal D(1)R-positive cells rescues this NOR deficit. Learning induces an enhancement of in vivo hippocampal long-term potentiation (LTP), which is absent in mutant mice. CB(1)R-mediated NOR and the associated LTP facilitation involve local control of GABAergic inhibition in a D(1)-dependent manner. This study reveals that hippocampal CB(1)R-/D(1)R-expressing interneurons control NOR memory, identifying a mechanism linking the diversity of hippocampal interneurons to specific behavioral outcomes.