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Elevation of Memory Cytotoxic T Lymphocytes, Including Human T Lymphotropic Virus Type 1 Tax-Specific and Hepatitis Virus Type C-Specific Cytotoxic T Lymphocytes, in a Patient with Adult T-Cell Leukemia/Lymphoma and Hepatocellular Carcinoma

Herein, we present the case of a patient who suffered from adult T-cell leukemia/lymphoma (ATLL) and hepatocellular carcinoma (HCC) after obtaining a sustained virological response following treatment with a direct-acting antiviral (DAA) at different points in time. The patient went into complete re...

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Autores principales: Jo, Tatsuro, Kaneko, Yohei, Oishi, Takayuki, Matsuzaka, Kaori, Shioya, Haruna, Sakai, Takahiro, Tomoinaga, Hiroo, Hayashi, Shizuka, Matsuo, Masatoshi, Taguchi, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443665/
https://www.ncbi.nlm.nih.gov/pubmed/32884522
http://dx.doi.org/10.1159/000508092
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author Jo, Tatsuro
Kaneko, Yohei
Oishi, Takayuki
Matsuzaka, Kaori
Shioya, Haruna
Sakai, Takahiro
Tomoinaga, Hiroo
Hayashi, Shizuka
Matsuo, Masatoshi
Taguchi, Jun
author_facet Jo, Tatsuro
Kaneko, Yohei
Oishi, Takayuki
Matsuzaka, Kaori
Shioya, Haruna
Sakai, Takahiro
Tomoinaga, Hiroo
Hayashi, Shizuka
Matsuo, Masatoshi
Taguchi, Jun
author_sort Jo, Tatsuro
collection PubMed
description Herein, we present the case of a patient who suffered from adult T-cell leukemia/lymphoma (ATLL) and hepatocellular carcinoma (HCC) after obtaining a sustained virological response following treatment with a direct-acting antiviral (DAA) at different points in time. The patient went into complete remission (CR) for ATLL. Unfortunately, subsequent relapse of ATLL was observed. This situation was overcome using chemotherapy with pegylated interferon alpha-2b. Human T lymphotropic virus type 1 Tax-specific cytotoxic T lymphocytes (CTLs) were recognized after obtaining second CR, and those CTLs have been maintained for many years. After 4 years from the second CR, chronic hepatitis type C was treated with a DAA, and sustained virological response was attained. However, the occurrence of HCC was detected. Surprisingly, the tumor disappeared spontaneously. Hepatitis virus type C-specific CTLs were also detected in the patient. T-cell receptor (TCR) V beta gene repertoire analyses revealed oligoclonal expansion of effector and memory CTLs. The number of CTLs expressing the TCR V beta 13.1 has increased over the years since HCC occurrence. The activation and maintenance of anticancer cellular immunity may have allowed the patient to obtain long-term survival and overcome two lethal neoplasms.
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spelling pubmed-74436652020-09-02 Elevation of Memory Cytotoxic T Lymphocytes, Including Human T Lymphotropic Virus Type 1 Tax-Specific and Hepatitis Virus Type C-Specific Cytotoxic T Lymphocytes, in a Patient with Adult T-Cell Leukemia/Lymphoma and Hepatocellular Carcinoma Jo, Tatsuro Kaneko, Yohei Oishi, Takayuki Matsuzaka, Kaori Shioya, Haruna Sakai, Takahiro Tomoinaga, Hiroo Hayashi, Shizuka Matsuo, Masatoshi Taguchi, Jun Case Rep Oncol Case Report Herein, we present the case of a patient who suffered from adult T-cell leukemia/lymphoma (ATLL) and hepatocellular carcinoma (HCC) after obtaining a sustained virological response following treatment with a direct-acting antiviral (DAA) at different points in time. The patient went into complete remission (CR) for ATLL. Unfortunately, subsequent relapse of ATLL was observed. This situation was overcome using chemotherapy with pegylated interferon alpha-2b. Human T lymphotropic virus type 1 Tax-specific cytotoxic T lymphocytes (CTLs) were recognized after obtaining second CR, and those CTLs have been maintained for many years. After 4 years from the second CR, chronic hepatitis type C was treated with a DAA, and sustained virological response was attained. However, the occurrence of HCC was detected. Surprisingly, the tumor disappeared spontaneously. Hepatitis virus type C-specific CTLs were also detected in the patient. T-cell receptor (TCR) V beta gene repertoire analyses revealed oligoclonal expansion of effector and memory CTLs. The number of CTLs expressing the TCR V beta 13.1 has increased over the years since HCC occurrence. The activation and maintenance of anticancer cellular immunity may have allowed the patient to obtain long-term survival and overcome two lethal neoplasms. S. Karger AG 2020-07-08 /pmc/articles/PMC7443665/ /pubmed/32884522 http://dx.doi.org/10.1159/000508092 Text en Copyright © 2020 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Jo, Tatsuro
Kaneko, Yohei
Oishi, Takayuki
Matsuzaka, Kaori
Shioya, Haruna
Sakai, Takahiro
Tomoinaga, Hiroo
Hayashi, Shizuka
Matsuo, Masatoshi
Taguchi, Jun
Elevation of Memory Cytotoxic T Lymphocytes, Including Human T Lymphotropic Virus Type 1 Tax-Specific and Hepatitis Virus Type C-Specific Cytotoxic T Lymphocytes, in a Patient with Adult T-Cell Leukemia/Lymphoma and Hepatocellular Carcinoma
title Elevation of Memory Cytotoxic T Lymphocytes, Including Human T Lymphotropic Virus Type 1 Tax-Specific and Hepatitis Virus Type C-Specific Cytotoxic T Lymphocytes, in a Patient with Adult T-Cell Leukemia/Lymphoma and Hepatocellular Carcinoma
title_full Elevation of Memory Cytotoxic T Lymphocytes, Including Human T Lymphotropic Virus Type 1 Tax-Specific and Hepatitis Virus Type C-Specific Cytotoxic T Lymphocytes, in a Patient with Adult T-Cell Leukemia/Lymphoma and Hepatocellular Carcinoma
title_fullStr Elevation of Memory Cytotoxic T Lymphocytes, Including Human T Lymphotropic Virus Type 1 Tax-Specific and Hepatitis Virus Type C-Specific Cytotoxic T Lymphocytes, in a Patient with Adult T-Cell Leukemia/Lymphoma and Hepatocellular Carcinoma
title_full_unstemmed Elevation of Memory Cytotoxic T Lymphocytes, Including Human T Lymphotropic Virus Type 1 Tax-Specific and Hepatitis Virus Type C-Specific Cytotoxic T Lymphocytes, in a Patient with Adult T-Cell Leukemia/Lymphoma and Hepatocellular Carcinoma
title_short Elevation of Memory Cytotoxic T Lymphocytes, Including Human T Lymphotropic Virus Type 1 Tax-Specific and Hepatitis Virus Type C-Specific Cytotoxic T Lymphocytes, in a Patient with Adult T-Cell Leukemia/Lymphoma and Hepatocellular Carcinoma
title_sort elevation of memory cytotoxic t lymphocytes, including human t lymphotropic virus type 1 tax-specific and hepatitis virus type c-specific cytotoxic t lymphocytes, in a patient with adult t-cell leukemia/lymphoma and hepatocellular carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443665/
https://www.ncbi.nlm.nih.gov/pubmed/32884522
http://dx.doi.org/10.1159/000508092
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