Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor

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The SARS-CoV-2 betacoronavirus uses its highly glycosylated trimeric Spike protein to bind to the cell surface receptor angiotensin converting enzyme 2 (ACE2) glycoprotein and facilitate host cell entry. We utilized glycomics-informed glycoproteomics to characterize site-specific microheterogeneity...

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Detalles Bibliográficos
Autores principales: Zhao, Peng, Praissman, Jeremy L., Grant, Oliver C., Cai, Yongfei, Xiao, Tianshu, Rosenbalm, Katelyn E., Aoki, Kazuhiro, Kellman, Benjamin P., Bridger, Robert, Barouch, Dan H., Brindley, Melinda A., Lewis, Nathan E., Tiemeyer, Michael, Chen, Bing, Woods, Robert J., Wells, Lance
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443692/
https://www.ncbi.nlm.nih.gov/pubmed/32841605
http://dx.doi.org/10.1016/j.chom.2020.08.004
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