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A novel colistin adjuvant identified by virtual screening for ArnT inhibitors

BACKGROUND: Colistin is a last-resort treatment option for many MDR Gram-negative bacteria. The covalent addition of l-aminoarabinose to the lipid A moiety of LPS is the main colistin resistance mechanism in the human pathogen Pseudomonas aeruginosa. OBJECTIVES: Identification (by in silico screenin...

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Detalles Bibliográficos
Autores principales:	Ghirga, Francesca, Stefanelli, Roberta, Cavinato, Luca, Lo Sciuto, Alessandra, Corradi, Silvia, Quaglio, Deborah, Calcaterra, Andrea, Casciaro, Bruno, Loffredo, Maria Rosa, Cappiello, Floriana, Morelli, Patrizia, Antonelli, Alberto, Rossolini, Gian Maria, Mangoni, Marialuisa, Mancone, Carmine, Botta, Bruno, Mori, Mattia, Ascenzioni, Fiorentina, Imperi, Francesco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443731/ https://www.ncbi.nlm.nih.gov/pubmed/32514531 http://dx.doi.org/10.1093/jac/dkaa200

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