Not just antibodies: B cells and T cells mediate immunity to COVID-19

Recent reports that antibodies to SARS-CoV-2 are not maintained in the serum following recovery from the virus have caused alarm. However, the absence of specific antibodies in the serum does not necessarily mean an absence of immune memory. Here, we discuss our current understanding of the relative...

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Detalles Bibliográficos
Autores principales: Cox, Rebecca J., Brokstad, Karl A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443809/
https://www.ncbi.nlm.nih.gov/pubmed/32839569
http://dx.doi.org/10.1038/s41577-020-00436-4
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author Cox, Rebecca J.
Brokstad, Karl A.
author_facet Cox, Rebecca J.
Brokstad, Karl A.
author_sort Cox, Rebecca J.
collection PubMed
description Recent reports that antibodies to SARS-CoV-2 are not maintained in the serum following recovery from the virus have caused alarm. However, the absence of specific antibodies in the serum does not necessarily mean an absence of immune memory. Here, we discuss our current understanding of the relative contribution of B cells and T cells to immunity to SARS-CoV-2 and the implications for the development of effective treatments and vaccines for COVID-19.
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spelling pubmed-74438092020-08-24 Not just antibodies: B cells and T cells mediate immunity to COVID-19 Cox, Rebecca J. Brokstad, Karl A. Nat Rev Immunol Comment Recent reports that antibodies to SARS-CoV-2 are not maintained in the serum following recovery from the virus have caused alarm. However, the absence of specific antibodies in the serum does not necessarily mean an absence of immune memory. Here, we discuss our current understanding of the relative contribution of B cells and T cells to immunity to SARS-CoV-2 and the implications for the development of effective treatments and vaccines for COVID-19. Nature Publishing Group UK 2020-08-24 2020 /pmc/articles/PMC7443809/ /pubmed/32839569 http://dx.doi.org/10.1038/s41577-020-00436-4 Text en © Springer Nature Limited 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Comment
Cox, Rebecca J.
Brokstad, Karl A.
Not just antibodies: B cells and T cells mediate immunity to COVID-19
title Not just antibodies: B cells and T cells mediate immunity to COVID-19
title_full Not just antibodies: B cells and T cells mediate immunity to COVID-19
title_fullStr Not just antibodies: B cells and T cells mediate immunity to COVID-19
title_full_unstemmed Not just antibodies: B cells and T cells mediate immunity to COVID-19
title_short Not just antibodies: B cells and T cells mediate immunity to COVID-19
title_sort not just antibodies: b cells and t cells mediate immunity to covid-19
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443809/
https://www.ncbi.nlm.nih.gov/pubmed/32839569
http://dx.doi.org/10.1038/s41577-020-00436-4
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