ALKBH5 regulates anti–PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment

Although immune checkpoint blockade (ICB) therapy has revolutionized cancer treatment, many patients do not respond or develop resistance to ICB. N(6)-methylation of adenosine (m(6)A) in RNA regulates many pathophysiological processes. Here, we show that deletion of the m(6)A demethylase Alkbh5 sens...

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Detalles Bibliográficos
Autores principales: Li, Na, Kang, Yuqi, Wang, Lingling, Huff, Sarah, Tang, Rachel, Hui, Hui, Agrawal, Kriti, Gonzalez, Gwendolyn Michelle, Wang, Yinsheng, Patel, Sandip Pravin, Rana, Tariq M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443867/
https://www.ncbi.nlm.nih.gov/pubmed/32747553
http://dx.doi.org/10.1073/pnas.1918986117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443867/
https://www.ncbi.nlm.nih.gov/pubmed/32747553
http://dx.doi.org/10.1073/pnas.1918986117

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