Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination

Mutation of HELLS (Helicase, Lymphoid-Specific)/Lsh in human DNA causes a severe immunodeficiency syndrome, but the nature of the defect remains unknown. We assessed here the role of Lsh in hematopoiesis using conditional Lsh knockout mice with expression of Mx1 or Vav Cre-recombinase. Bone marrow t...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Yafeng, Ren, Jianke, Xu, Xiaoping, Ni, Kai, Schwader, Andrew, Finney, Richard, Wang, Can, Sun, Lei, Klarmann, Kimberly, Keller, Jonathan, Tubbs, Anthony, Nussenzweig, Andre, Muegge, Kathrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443918/
https://www.ncbi.nlm.nih.gov/pubmed/32727902
http://dx.doi.org/10.1073/pnas.2004112117

Ejemplares similares

Ejemplares similares