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Hidden kinetic traps in multidomain folding highlight the presence of a misfolded but functionally competent intermediate
Although more than 75% of the proteome is composed of multidomain proteins, current knowledge of protein folding is based primarily on studies of isolated domains. In this work, we describe the folding mechanism of a multidomain tandem construct comprising two distinct covalently bound PDZ domains b...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443948/ https://www.ncbi.nlm.nih.gov/pubmed/32747559 http://dx.doi.org/10.1073/pnas.2004138117 |