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Association between a DJ-1 polymorphism and the risk of Parkinson's disease: a PRISMA-compliant systematic review and meta-analysis

OBJECTIVE: In recent years, a number of case–control studies have focused on the association between the DJ-1 g.168_185del polymorphism and the risk of Parkinson's disease (PD). However, the results have been conflicting. To estimate the relationship between the DJ-1 g.168_185del polymorphism a...

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Autores principales: Liu, Jie, Li, Chunrong, Zhou, Xiaoyang, Sun, Jian, Zhu, Meng, Zhang, Hongliang, Cheng, Lei, Li, Guobin, He, Tao, Deng, Wenshuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444142/
https://www.ncbi.nlm.nih.gov/pubmed/32814486
http://dx.doi.org/10.1177/0300060520947943
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author Liu, Jie
Li, Chunrong
Zhou, Xiaoyang
Sun, Jian
Zhu, Meng
Zhang, Hongliang
Cheng, Lei
Li, Guobin
He, Tao
Deng, Wenshuai
author_facet Liu, Jie
Li, Chunrong
Zhou, Xiaoyang
Sun, Jian
Zhu, Meng
Zhang, Hongliang
Cheng, Lei
Li, Guobin
He, Tao
Deng, Wenshuai
author_sort Liu, Jie
collection PubMed
description OBJECTIVE: In recent years, a number of case–control studies have focused on the association between the DJ-1 g.168_185del polymorphism and the risk of Parkinson's disease (PD). However, the results have been conflicting. To estimate the relationship between the DJ-1 g.168_185del polymorphism and PD susceptibility, a comprehensive meta-analysis was performed. METHODS: Eligible studies concerning the DJ-1 g.168_185del polymorphism and PD susceptibility were searched for in the PubMed, Web of Science, Embase, Wanfang, CNKI, and VIP databases. Odds ratios and 95% confidence intervals were calculated to estimate the strength of the associations. In total, 11 studies were included in this meta-analysis, including 13 case–control studies with 2890 cases and 3043 controls. RESULTS: This meta-analysis revealed that DJ-1 g.168_185del variants are associated with PD susceptibility in the non-Asian population, but not in the Asian population. CONCLUSIONS: Our meta-analysis suggests that DJ-1 gene variants are not associated with the risk of PD in the overall population.
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spelling pubmed-74441422020-09-09 Association between a DJ-1 polymorphism and the risk of Parkinson's disease: a PRISMA-compliant systematic review and meta-analysis Liu, Jie Li, Chunrong Zhou, Xiaoyang Sun, Jian Zhu, Meng Zhang, Hongliang Cheng, Lei Li, Guobin He, Tao Deng, Wenshuai J Int Med Res Special Issue: Vestibular System and its Disorders: Clinical Neurophysiology, Diagnosis, Treatment and Rehabilitation OBJECTIVE: In recent years, a number of case–control studies have focused on the association between the DJ-1 g.168_185del polymorphism and the risk of Parkinson's disease (PD). However, the results have been conflicting. To estimate the relationship between the DJ-1 g.168_185del polymorphism and PD susceptibility, a comprehensive meta-analysis was performed. METHODS: Eligible studies concerning the DJ-1 g.168_185del polymorphism and PD susceptibility were searched for in the PubMed, Web of Science, Embase, Wanfang, CNKI, and VIP databases. Odds ratios and 95% confidence intervals were calculated to estimate the strength of the associations. In total, 11 studies were included in this meta-analysis, including 13 case–control studies with 2890 cases and 3043 controls. RESULTS: This meta-analysis revealed that DJ-1 g.168_185del variants are associated with PD susceptibility in the non-Asian population, but not in the Asian population. CONCLUSIONS: Our meta-analysis suggests that DJ-1 gene variants are not associated with the risk of PD in the overall population. SAGE Publications 2020-08-20 /pmc/articles/PMC7444142/ /pubmed/32814486 http://dx.doi.org/10.1177/0300060520947943 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Special Issue: Vestibular System and its Disorders: Clinical Neurophysiology, Diagnosis, Treatment and Rehabilitation
Liu, Jie
Li, Chunrong
Zhou, Xiaoyang
Sun, Jian
Zhu, Meng
Zhang, Hongliang
Cheng, Lei
Li, Guobin
He, Tao
Deng, Wenshuai
Association between a DJ-1 polymorphism and the risk of Parkinson's disease: a PRISMA-compliant systematic review and meta-analysis
title Association between a DJ-1 polymorphism and the risk of Parkinson's disease: a PRISMA-compliant systematic review and meta-analysis
title_full Association between a DJ-1 polymorphism and the risk of Parkinson's disease: a PRISMA-compliant systematic review and meta-analysis
title_fullStr Association between a DJ-1 polymorphism and the risk of Parkinson's disease: a PRISMA-compliant systematic review and meta-analysis
title_full_unstemmed Association between a DJ-1 polymorphism and the risk of Parkinson's disease: a PRISMA-compliant systematic review and meta-analysis
title_short Association between a DJ-1 polymorphism and the risk of Parkinson's disease: a PRISMA-compliant systematic review and meta-analysis
title_sort association between a dj-1 polymorphism and the risk of parkinson's disease: a prisma-compliant systematic review and meta-analysis
topic Special Issue: Vestibular System and its Disorders: Clinical Neurophysiology, Diagnosis, Treatment and Rehabilitation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444142/
https://www.ncbi.nlm.nih.gov/pubmed/32814486
http://dx.doi.org/10.1177/0300060520947943
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