SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19

SARS-CoV-2 antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome in children (MIS-C) possess higher SARS-CoV-2 spike IgG titers compared to those with severe coronavirus disease 2019 (COVID-19), likely reflecting a lo...

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Autores principales: Anderson, Elizabeth M., Diorio, Caroline, Goodwin, Eileen C., McNerney, Kevin O., Weirick, Madison E., Gouma, Sigrid, Bolton, Marcus J., Arevalo, Claudia P., Chase, Julie, Hicks, Philip, Manzoni, Tomaz B., Baxter, Amy E., Andrea, Kurt P., Burudpakdee, Chakkapong, Lee, Jessica H., Vella, Laura A., Henrickson, Sarah E., Harris, Rebecca M., Wherry, E. John, Bates, Paul, Bassiri, Hamid, Behrens, Edward M., Teachey, David T., Hensley, Scott E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444298/
https://www.ncbi.nlm.nih.gov/pubmed/32839782
http://dx.doi.org/10.1101/2020.08.17.20176552
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author Anderson, Elizabeth M.
Diorio, Caroline
Goodwin, Eileen C.
McNerney, Kevin O.
Weirick, Madison E.
Gouma, Sigrid
Bolton, Marcus J.
Arevalo, Claudia P.
Chase, Julie
Hicks, Philip
Manzoni, Tomaz B.
Baxter, Amy E.
Andrea, Kurt P.
Burudpakdee, Chakkapong
Lee, Jessica H.
Vella, Laura A.
Henrickson, Sarah E.
Harris, Rebecca M.
Wherry, E. John
Bates, Paul
Bassiri, Hamid
Behrens, Edward M.
Teachey, David T.
Hensley, Scott E.
author_facet Anderson, Elizabeth M.
Diorio, Caroline
Goodwin, Eileen C.
McNerney, Kevin O.
Weirick, Madison E.
Gouma, Sigrid
Bolton, Marcus J.
Arevalo, Claudia P.
Chase, Julie
Hicks, Philip
Manzoni, Tomaz B.
Baxter, Amy E.
Andrea, Kurt P.
Burudpakdee, Chakkapong
Lee, Jessica H.
Vella, Laura A.
Henrickson, Sarah E.
Harris, Rebecca M.
Wherry, E. John
Bates, Paul
Bassiri, Hamid
Behrens, Edward M.
Teachey, David T.
Hensley, Scott E.
author_sort Anderson, Elizabeth M.
collection PubMed
description SARS-CoV-2 antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome in children (MIS-C) possess higher SARS-CoV-2 spike IgG titers compared to those with severe coronavirus disease 2019 (COVID-19), likely reflecting a longer time since onset of infection in MIS-C patients.
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spelling pubmed-74442982020-08-25 SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19 Anderson, Elizabeth M. Diorio, Caroline Goodwin, Eileen C. McNerney, Kevin O. Weirick, Madison E. Gouma, Sigrid Bolton, Marcus J. Arevalo, Claudia P. Chase, Julie Hicks, Philip Manzoni, Tomaz B. Baxter, Amy E. Andrea, Kurt P. Burudpakdee, Chakkapong Lee, Jessica H. Vella, Laura A. Henrickson, Sarah E. Harris, Rebecca M. Wherry, E. John Bates, Paul Bassiri, Hamid Behrens, Edward M. Teachey, David T. Hensley, Scott E. medRxiv Article SARS-CoV-2 antibody responses in children remain poorly characterized. Here, we show that pediatric patients with multisystem inflammatory syndrome in children (MIS-C) possess higher SARS-CoV-2 spike IgG titers compared to those with severe coronavirus disease 2019 (COVID-19), likely reflecting a longer time since onset of infection in MIS-C patients. Cold Spring Harbor Laboratory 2020-08-18 /pmc/articles/PMC7444298/ /pubmed/32839782 http://dx.doi.org/10.1101/2020.08.17.20176552 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/It is made available under a CC-BY-NC-ND 4.0 International license (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Article
Anderson, Elizabeth M.
Diorio, Caroline
Goodwin, Eileen C.
McNerney, Kevin O.
Weirick, Madison E.
Gouma, Sigrid
Bolton, Marcus J.
Arevalo, Claudia P.
Chase, Julie
Hicks, Philip
Manzoni, Tomaz B.
Baxter, Amy E.
Andrea, Kurt P.
Burudpakdee, Chakkapong
Lee, Jessica H.
Vella, Laura A.
Henrickson, Sarah E.
Harris, Rebecca M.
Wherry, E. John
Bates, Paul
Bassiri, Hamid
Behrens, Edward M.
Teachey, David T.
Hensley, Scott E.
SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19
title SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19
title_full SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19
title_fullStr SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19
title_full_unstemmed SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19
title_short SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19
title_sort sars-cov-2 antibody responses in children with mis-c and mild and severe covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444298/
https://www.ncbi.nlm.nih.gov/pubmed/32839782
http://dx.doi.org/10.1101/2020.08.17.20176552
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