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Protective effect and mechanism of mesenchymal stem cells on heat stroke induced intestinal injury
Heat stroke (HS) is considered to be a severe systemic inflammatory reaction disease that is caused by high fever. The mortality of HS is high worldwide due to the lack of effective treatments. Presently, mesenchymal stem cells (MSCs) have been demonstrated to serve roles in inflammation and immune...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444330/ https://www.ncbi.nlm.nih.gov/pubmed/32855671 http://dx.doi.org/10.3892/etm.2020.9051 |
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author | Wang, Lu Deng, Zihui Yuan, Rui Zhao, Yan Yang, Mengmeng Hu, Jie Zhang, Yu Li, Yun Zhou, Feihu Kang, Hongjun |
author_facet | Wang, Lu Deng, Zihui Yuan, Rui Zhao, Yan Yang, Mengmeng Hu, Jie Zhang, Yu Li, Yun Zhou, Feihu Kang, Hongjun |
author_sort | Wang, Lu |
collection | PubMed |
description | Heat stroke (HS) is considered to be a severe systemic inflammatory reaction disease that is caused by high fever. The mortality of HS is high worldwide due to the lack of effective treatments. Presently, mesenchymal stem cells (MSCs) have been demonstrated to serve roles in inflammation and immune regulation. Therefore, the current study aimed to investigate the protective effect and mechanism of MSCs against the HS-induced inflammatory response and organ dysfunction. A rat model of HS was induced by a high-temperature environment and treated with MSCs via tail veins. The levels of molecular markers of organ function, inflammatory factors and chemokines were examined at days 1, 7, 14 and 28. Histological staining was performed on the intestines of rats and control groups, and the Chiu's scores of the two groups were compared. The results revealed that MSCs injection significantly reduced the mortality and inhibited the circulatory inflammatory response. Additionally, main organ function, such as in the liver and kidney, were significantly improved following MSCs infusion in HS rats. Furthermore, MSCs treatment significantly improved edema, necrosis and villus exfoliation of intestinal mucosa, and reduced the inflammatory response of intestinal tissue. These results indicated that MSC infusion had therapeutic effects on HS of rats by regulating the circulatory and intestinal inflammatory response. Moreover, MSCs may be able to protect organ function and promote tissue repair in HS. The results of the current study indicated that MSCs may be used as a potential method to treat HS and the resulting organ dysfunction. |
format | Online Article Text |
id | pubmed-7444330 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-74443302020-08-26 Protective effect and mechanism of mesenchymal stem cells on heat stroke induced intestinal injury Wang, Lu Deng, Zihui Yuan, Rui Zhao, Yan Yang, Mengmeng Hu, Jie Zhang, Yu Li, Yun Zhou, Feihu Kang, Hongjun Exp Ther Med Articles Heat stroke (HS) is considered to be a severe systemic inflammatory reaction disease that is caused by high fever. The mortality of HS is high worldwide due to the lack of effective treatments. Presently, mesenchymal stem cells (MSCs) have been demonstrated to serve roles in inflammation and immune regulation. Therefore, the current study aimed to investigate the protective effect and mechanism of MSCs against the HS-induced inflammatory response and organ dysfunction. A rat model of HS was induced by a high-temperature environment and treated with MSCs via tail veins. The levels of molecular markers of organ function, inflammatory factors and chemokines were examined at days 1, 7, 14 and 28. Histological staining was performed on the intestines of rats and control groups, and the Chiu's scores of the two groups were compared. The results revealed that MSCs injection significantly reduced the mortality and inhibited the circulatory inflammatory response. Additionally, main organ function, such as in the liver and kidney, were significantly improved following MSCs infusion in HS rats. Furthermore, MSCs treatment significantly improved edema, necrosis and villus exfoliation of intestinal mucosa, and reduced the inflammatory response of intestinal tissue. These results indicated that MSC infusion had therapeutic effects on HS of rats by regulating the circulatory and intestinal inflammatory response. Moreover, MSCs may be able to protect organ function and promote tissue repair in HS. The results of the current study indicated that MSCs may be used as a potential method to treat HS and the resulting organ dysfunction. D.A. Spandidos 2020-10 2020-07-27 /pmc/articles/PMC7444330/ /pubmed/32855671 http://dx.doi.org/10.3892/etm.2020.9051 Text en Copyright: © Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Wang, Lu Deng, Zihui Yuan, Rui Zhao, Yan Yang, Mengmeng Hu, Jie Zhang, Yu Li, Yun Zhou, Feihu Kang, Hongjun Protective effect and mechanism of mesenchymal stem cells on heat stroke induced intestinal injury |
title | Protective effect and mechanism of mesenchymal stem cells on heat stroke induced intestinal injury |
title_full | Protective effect and mechanism of mesenchymal stem cells on heat stroke induced intestinal injury |
title_fullStr | Protective effect and mechanism of mesenchymal stem cells on heat stroke induced intestinal injury |
title_full_unstemmed | Protective effect and mechanism of mesenchymal stem cells on heat stroke induced intestinal injury |
title_short | Protective effect and mechanism of mesenchymal stem cells on heat stroke induced intestinal injury |
title_sort | protective effect and mechanism of mesenchymal stem cells on heat stroke induced intestinal injury |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444330/ https://www.ncbi.nlm.nih.gov/pubmed/32855671 http://dx.doi.org/10.3892/etm.2020.9051 |
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