Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development

Microglial cells play a key role in brain homeostasis from development to adulthood. Here we show the involvement of a site-specific phosphorylation of Presenilin 1 (PS1) in microglial development. Profiles of microglia-specific transcripts in different temporal stages of development, combined with...

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Detalles Bibliográficos
Autores principales: Ledo, Jose Henrique, Zhang, Ran, Mesin, Luka, Mourão-Sá, Diego, Azevedo, Estefania P., Troyanskaya, Olga G., Bustos, Victor, Greengard, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444478/
https://www.ncbi.nlm.nih.gov/pubmed/32822378
http://dx.doi.org/10.1371/journal.pone.0237773

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