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The frequent complete subgraphs in the human connectome

While it is still not possible to describe the neuronal-level connections of the human brain, we can map the human connectome with several hundred vertices, by the application of diffusion-MRI based techniques. In these graphs, the nodes correspond to anatomically identified gray matter areas of the...

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Autores principales: Fellner, Máté, Varga, Bálint, Grolmusz, Vince
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444532/
https://www.ncbi.nlm.nih.gov/pubmed/32817642
http://dx.doi.org/10.1371/journal.pone.0236883
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author Fellner, Máté
Varga, Bálint
Grolmusz, Vince
author_facet Fellner, Máté
Varga, Bálint
Grolmusz, Vince
author_sort Fellner, Máté
collection PubMed
description While it is still not possible to describe the neuronal-level connections of the human brain, we can map the human connectome with several hundred vertices, by the application of diffusion-MRI based techniques. In these graphs, the nodes correspond to anatomically identified gray matter areas of the brain, while the edges correspond to the axonal fibers, connecting these areas. In our previous contributions, we have described numerous graph-theoretical phenomena of the human connectomes. Here we map the frequent complete subgraphs of the human brain networks: in these subgraphs, every pair of vertices is connected by an edge. We also examine sex differences in the results. The mapping of the frequent subgraphs gives robust substructures in the graph: if a subgraph is present in the 80% of the graphs, then, most probably, it could not be an artifact of the measurement or the data processing workflow. We list here the frequent complete subgraphs of the human braingraphs of 413 subjects (238 women and 175 men), each with 463 nodes, with a frequency threshold of 80%, and identify 812 complete subgraphs, which are more frequent in male and 224 complete subgraphs, which are more frequent in female connectomes.
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spelling pubmed-74445322020-08-27 The frequent complete subgraphs in the human connectome Fellner, Máté Varga, Bálint Grolmusz, Vince PLoS One Research Article While it is still not possible to describe the neuronal-level connections of the human brain, we can map the human connectome with several hundred vertices, by the application of diffusion-MRI based techniques. In these graphs, the nodes correspond to anatomically identified gray matter areas of the brain, while the edges correspond to the axonal fibers, connecting these areas. In our previous contributions, we have described numerous graph-theoretical phenomena of the human connectomes. Here we map the frequent complete subgraphs of the human brain networks: in these subgraphs, every pair of vertices is connected by an edge. We also examine sex differences in the results. The mapping of the frequent subgraphs gives robust substructures in the graph: if a subgraph is present in the 80% of the graphs, then, most probably, it could not be an artifact of the measurement or the data processing workflow. We list here the frequent complete subgraphs of the human braingraphs of 413 subjects (238 women and 175 men), each with 463 nodes, with a frequency threshold of 80%, and identify 812 complete subgraphs, which are more frequent in male and 224 complete subgraphs, which are more frequent in female connectomes. Public Library of Science 2020-08-20 /pmc/articles/PMC7444532/ /pubmed/32817642 http://dx.doi.org/10.1371/journal.pone.0236883 Text en © 2020 Fellner et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Fellner, Máté
Varga, Bálint
Grolmusz, Vince
The frequent complete subgraphs in the human connectome
title The frequent complete subgraphs in the human connectome
title_full The frequent complete subgraphs in the human connectome
title_fullStr The frequent complete subgraphs in the human connectome
title_full_unstemmed The frequent complete subgraphs in the human connectome
title_short The frequent complete subgraphs in the human connectome
title_sort frequent complete subgraphs in the human connectome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444532/
https://www.ncbi.nlm.nih.gov/pubmed/32817642
http://dx.doi.org/10.1371/journal.pone.0236883
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