Inverse correlation between levels of glycated haemoglobin and expression levels of SERCA protein in Mexican patients with type 2 diabetes mellitus

We examined the association between sarco/endoplasmic reticulum calcium ATPase (SERCA) expression and glycated hemoglobin (HbA(1c)) levels since alterations in this protein expression are associated with the genesis of insulin resistance. HbA1c levels and SERCA protein expression from platelets of M...

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Autores principales: Galindo-Hernandez, Octavio, Machado-Contreras, Jesus Rene, Martinez-Corella, Rodrigo, Romero-Garcia, Tatiana, Vazquez-Jimenez, J. Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2020
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444701/
https://www.ncbi.nlm.nih.gov/pubmed/32864012
http://dx.doi.org/10.5114/aoms.2020.97970
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author Galindo-Hernandez, Octavio
Machado-Contreras, Jesus Rene
Martinez-Corella, Rodrigo
Romero-Garcia, Tatiana
Vazquez-Jimenez, J. Gustavo
author_facet Galindo-Hernandez, Octavio
Machado-Contreras, Jesus Rene
Martinez-Corella, Rodrigo
Romero-Garcia, Tatiana
Vazquez-Jimenez, J. Gustavo
author_sort Galindo-Hernandez, Octavio
collection PubMed
description We examined the association between sarco/endoplasmic reticulum calcium ATPase (SERCA) expression and glycated hemoglobin (HbA(1c)) levels since alterations in this protein expression are associated with the genesis of insulin resistance. HbA1c levels and SERCA protein expression from platelets of Mexican patients diagnosed with type 2 diabetes mellitus (T2DM) were analyzed showing lower values of SERCA expression against the normal values we find in healthy people. Interestingly, as diabetes condition got worse; SERCA protein expression decreased gradually until it was undetectable. The results showed an inverse correlation between HbA(1c) and SERCA protein expression in T2DM patients. .
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spelling pubmed-74447012020-08-28 Inverse correlation between levels of glycated haemoglobin and expression levels of SERCA protein in Mexican patients with type 2 diabetes mellitus Galindo-Hernandez, Octavio Machado-Contreras, Jesus Rene Martinez-Corella, Rodrigo Romero-Garcia, Tatiana Vazquez-Jimenez, J. Gustavo Arch Med Sci Short Report We examined the association between sarco/endoplasmic reticulum calcium ATPase (SERCA) expression and glycated hemoglobin (HbA(1c)) levels since alterations in this protein expression are associated with the genesis of insulin resistance. HbA1c levels and SERCA protein expression from platelets of Mexican patients diagnosed with type 2 diabetes mellitus (T2DM) were analyzed showing lower values of SERCA expression against the normal values we find in healthy people. Interestingly, as diabetes condition got worse; SERCA protein expression decreased gradually until it was undetectable. The results showed an inverse correlation between HbA(1c) and SERCA protein expression in T2DM patients. . Termedia Publishing House 2020-08-10 /pmc/articles/PMC7444701/ /pubmed/32864012 http://dx.doi.org/10.5114/aoms.2020.97970 Text en Copyright: © 2020 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Short Report
Galindo-Hernandez, Octavio
Machado-Contreras, Jesus Rene
Martinez-Corella, Rodrigo
Romero-Garcia, Tatiana
Vazquez-Jimenez, J. Gustavo
Inverse correlation between levels of glycated haemoglobin and expression levels of SERCA protein in Mexican patients with type 2 diabetes mellitus
title Inverse correlation between levels of glycated haemoglobin and expression levels of SERCA protein in Mexican patients with type 2 diabetes mellitus
title_full Inverse correlation between levels of glycated haemoglobin and expression levels of SERCA protein in Mexican patients with type 2 diabetes mellitus
title_fullStr Inverse correlation between levels of glycated haemoglobin and expression levels of SERCA protein in Mexican patients with type 2 diabetes mellitus
title_full_unstemmed Inverse correlation between levels of glycated haemoglobin and expression levels of SERCA protein in Mexican patients with type 2 diabetes mellitus
title_short Inverse correlation between levels of glycated haemoglobin and expression levels of SERCA protein in Mexican patients with type 2 diabetes mellitus
title_sort inverse correlation between levels of glycated haemoglobin and expression levels of serca protein in mexican patients with type 2 diabetes mellitus
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444701/
https://www.ncbi.nlm.nih.gov/pubmed/32864012
http://dx.doi.org/10.5114/aoms.2020.97970
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