Increasing Drug Resistance Among Persons With Tuberculosis in Massachusetts, 2009–2018

We examined Massachusetts tuberculosis surveillance data from to 2009 to 2018. Of 1533 culture-confirmed cases, 190 (12.4%) demonstrated resistance to isoniazid including 32 (2.1%) with rifampin resistance. In multivariable analysis, isoniazid resistance increased significantly over time (per-year o...

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Detalles Bibliográficos
Autores principales: Eddy, Jared J, Gadani, Kavita M, Tibbs, Andrew, Bernardo, John, Cochran, Jennifer, White, Laura F, Horsburgh, C Robert, Jacobson, Karen R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444736/
https://www.ncbi.nlm.nih.gov/pubmed/32855987
http://dx.doi.org/10.1093/ofid/ofaa300
Descripción
Sumario:We examined Massachusetts tuberculosis surveillance data from to 2009 to 2018. Of 1533 culture-confirmed cases, 190 (12.4%) demonstrated resistance to isoniazid including 32 (2.1%) with rifampin resistance. In multivariable analysis, isoniazid resistance increased significantly over time (per-year odds ratio = 1.07, 95% confidence interval = 1.01–1.13, P = .018) and was associated with younger age, foreign birth, and prior tuberculosis treatment.

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