Diarrhea or No Diarrhea, It Still Hurts: An Atypical Case of Clostridioides difficile

Clostridioides difficile (C. difficile) is a common nosocomial infection that is classically described as profuse watery diarrhea in hospitalized patients after antibiotic use. We present a case of a 76-year-old female who presented to our emergency room with diffuse abdominal pain after consuming meals. This patient had completed treatment with oral vancomycin for C. difficile infection two weeks prior to admission and had been asymptomatic until this point. After receiving treatments for presumed acute mesenteric ischemia did not yield clinical improvement, polymerase chain reaction for C. difficile stool antigen was tested and was positive. While the patient did not have diarrhea, the classical feature of C. difficile infection, she quickly improved after treatment with oral vancomycin.