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Novel Use of Calcimimetic Activity to Diagnose Primary Hyperparathyroidism in a Patient With Persistently Low-Normal Parathyroid Hormone Level
Primary hyperparathyroidism (PHPT) is the most common etiology of hypercalcemia in the ambulatory setting and usually presents with an intact parathyroid hormone (PTH) level that is elevated or inappropriately near the upper limit of the laboratory reference range. However, PHPT with low-normal PTH...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444985/ https://www.ncbi.nlm.nih.gov/pubmed/32850231 http://dx.doi.org/10.7759/cureus.9360 |
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author | Bandaru, Sindhura Manthri, Sukesh Nallala, Deepika Mamillapalli, Chaitanya K Jakoby, Michael G |
author_facet | Bandaru, Sindhura Manthri, Sukesh Nallala, Deepika Mamillapalli, Chaitanya K Jakoby, Michael G |
author_sort | Bandaru, Sindhura |
collection | PubMed |
description | Primary hyperparathyroidism (PHPT) is the most common etiology of hypercalcemia in the ambulatory setting and usually presents with an intact parathyroid hormone (PTH) level that is elevated or inappropriately near the upper limit of the laboratory reference range. However, PHPT with low-normal PTH level is reported in the peer-reviewed literature, and this atypical presentation may delay diagnosis of PHPT. We present a case of PHPT with persistently low-normal PTH level in which the PTH dependence of hypercalcemia was demonstrated by the response to treatment with the calcimimetic agent cinacalcet. |
format | Online Article Text |
id | pubmed-7444985 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-74449852020-08-25 Novel Use of Calcimimetic Activity to Diagnose Primary Hyperparathyroidism in a Patient With Persistently Low-Normal Parathyroid Hormone Level Bandaru, Sindhura Manthri, Sukesh Nallala, Deepika Mamillapalli, Chaitanya K Jakoby, Michael G Cureus Endocrinology/Diabetes/Metabolism Primary hyperparathyroidism (PHPT) is the most common etiology of hypercalcemia in the ambulatory setting and usually presents with an intact parathyroid hormone (PTH) level that is elevated or inappropriately near the upper limit of the laboratory reference range. However, PHPT with low-normal PTH level is reported in the peer-reviewed literature, and this atypical presentation may delay diagnosis of PHPT. We present a case of PHPT with persistently low-normal PTH level in which the PTH dependence of hypercalcemia was demonstrated by the response to treatment with the calcimimetic agent cinacalcet. Cureus 2020-07-23 /pmc/articles/PMC7444985/ /pubmed/32850231 http://dx.doi.org/10.7759/cureus.9360 Text en Copyright © 2020, Bandaru et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Endocrinology/Diabetes/Metabolism Bandaru, Sindhura Manthri, Sukesh Nallala, Deepika Mamillapalli, Chaitanya K Jakoby, Michael G Novel Use of Calcimimetic Activity to Diagnose Primary Hyperparathyroidism in a Patient With Persistently Low-Normal Parathyroid Hormone Level |
title | Novel Use of Calcimimetic Activity to Diagnose Primary Hyperparathyroidism in a Patient With Persistently Low-Normal Parathyroid Hormone Level |
title_full | Novel Use of Calcimimetic Activity to Diagnose Primary Hyperparathyroidism in a Patient With Persistently Low-Normal Parathyroid Hormone Level |
title_fullStr | Novel Use of Calcimimetic Activity to Diagnose Primary Hyperparathyroidism in a Patient With Persistently Low-Normal Parathyroid Hormone Level |
title_full_unstemmed | Novel Use of Calcimimetic Activity to Diagnose Primary Hyperparathyroidism in a Patient With Persistently Low-Normal Parathyroid Hormone Level |
title_short | Novel Use of Calcimimetic Activity to Diagnose Primary Hyperparathyroidism in a Patient With Persistently Low-Normal Parathyroid Hormone Level |
title_sort | novel use of calcimimetic activity to diagnose primary hyperparathyroidism in a patient with persistently low-normal parathyroid hormone level |
topic | Endocrinology/Diabetes/Metabolism |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444985/ https://www.ncbi.nlm.nih.gov/pubmed/32850231 http://dx.doi.org/10.7759/cureus.9360 |
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