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Novel Use of Calcimimetic Activity to Diagnose Primary Hyperparathyroidism in a Patient With Persistently Low-Normal Parathyroid Hormone Level

Primary hyperparathyroidism (PHPT) is the most common etiology of hypercalcemia in the ambulatory setting and usually presents with an intact parathyroid hormone (PTH) level that is elevated or inappropriately near the upper limit of the laboratory reference range. However, PHPT with low-normal PTH...

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Autores principales: Bandaru, Sindhura, Manthri, Sukesh, Nallala, Deepika, Mamillapalli, Chaitanya K, Jakoby, Michael G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444985/
https://www.ncbi.nlm.nih.gov/pubmed/32850231
http://dx.doi.org/10.7759/cureus.9360
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author Bandaru, Sindhura
Manthri, Sukesh
Nallala, Deepika
Mamillapalli, Chaitanya K
Jakoby, Michael G
author_facet Bandaru, Sindhura
Manthri, Sukesh
Nallala, Deepika
Mamillapalli, Chaitanya K
Jakoby, Michael G
author_sort Bandaru, Sindhura
collection PubMed
description Primary hyperparathyroidism (PHPT) is the most common etiology of hypercalcemia in the ambulatory setting and usually presents with an intact parathyroid hormone (PTH) level that is elevated or inappropriately near the upper limit of the laboratory reference range. However, PHPT with low-normal PTH level is reported in the peer-reviewed literature, and this atypical presentation may delay diagnosis of PHPT. We present a case of PHPT with persistently low-normal PTH level in which the PTH dependence of hypercalcemia was demonstrated by the response to treatment with the calcimimetic agent cinacalcet.
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spelling pubmed-74449852020-08-25 Novel Use of Calcimimetic Activity to Diagnose Primary Hyperparathyroidism in a Patient With Persistently Low-Normal Parathyroid Hormone Level Bandaru, Sindhura Manthri, Sukesh Nallala, Deepika Mamillapalli, Chaitanya K Jakoby, Michael G Cureus Endocrinology/Diabetes/Metabolism Primary hyperparathyroidism (PHPT) is the most common etiology of hypercalcemia in the ambulatory setting and usually presents with an intact parathyroid hormone (PTH) level that is elevated or inappropriately near the upper limit of the laboratory reference range. However, PHPT with low-normal PTH level is reported in the peer-reviewed literature, and this atypical presentation may delay diagnosis of PHPT. We present a case of PHPT with persistently low-normal PTH level in which the PTH dependence of hypercalcemia was demonstrated by the response to treatment with the calcimimetic agent cinacalcet. Cureus 2020-07-23 /pmc/articles/PMC7444985/ /pubmed/32850231 http://dx.doi.org/10.7759/cureus.9360 Text en Copyright © 2020, Bandaru et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Bandaru, Sindhura
Manthri, Sukesh
Nallala, Deepika
Mamillapalli, Chaitanya K
Jakoby, Michael G
Novel Use of Calcimimetic Activity to Diagnose Primary Hyperparathyroidism in a Patient With Persistently Low-Normal Parathyroid Hormone Level
title Novel Use of Calcimimetic Activity to Diagnose Primary Hyperparathyroidism in a Patient With Persistently Low-Normal Parathyroid Hormone Level
title_full Novel Use of Calcimimetic Activity to Diagnose Primary Hyperparathyroidism in a Patient With Persistently Low-Normal Parathyroid Hormone Level
title_fullStr Novel Use of Calcimimetic Activity to Diagnose Primary Hyperparathyroidism in a Patient With Persistently Low-Normal Parathyroid Hormone Level
title_full_unstemmed Novel Use of Calcimimetic Activity to Diagnose Primary Hyperparathyroidism in a Patient With Persistently Low-Normal Parathyroid Hormone Level
title_short Novel Use of Calcimimetic Activity to Diagnose Primary Hyperparathyroidism in a Patient With Persistently Low-Normal Parathyroid Hormone Level
title_sort novel use of calcimimetic activity to diagnose primary hyperparathyroidism in a patient with persistently low-normal parathyroid hormone level
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444985/
https://www.ncbi.nlm.nih.gov/pubmed/32850231
http://dx.doi.org/10.7759/cureus.9360
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