Pseudocirrhosis in Chronic Budd Chiari Syndrome With Janus Tyrosine Kinase 2 (JAK2) Mutation

Budd-Chiari syndrome (BCS) occurs when there is hepatic venous outflow obstruction. Chronic BCS may result in liver cirrhosis due to long-standing obstruction and tend to present late. We present the first case of BCS secondary to Janus tyrosine kinase 2 (JAK2) mutation resulting in "pseudocirr...

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Autores principales: Lakshmanan, Seetha, Baskaran, Dhanya, Onkarappa Mangala, Yashvin, Toubia, Nabil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444998/
https://www.ncbi.nlm.nih.gov/pubmed/32850227
http://dx.doi.org/10.7759/cureus.9355
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author Lakshmanan, Seetha
Baskaran, Dhanya
Onkarappa Mangala, Yashvin
Toubia, Nabil
author_facet Lakshmanan, Seetha
Baskaran, Dhanya
Onkarappa Mangala, Yashvin
Toubia, Nabil
author_sort Lakshmanan, Seetha
collection PubMed
description Budd-Chiari syndrome (BCS) occurs when there is hepatic venous outflow obstruction. Chronic BCS may result in liver cirrhosis due to long-standing obstruction and tend to present late. We present the first case of BCS secondary to Janus tyrosine kinase 2 (JAK2) mutation resulting in "pseudocirrhosis" rather than cirrhosis of the liver. Pseudocirrhosis clinically and radiologically mimics cirrhosis without the classical histopathological changes, and it is usually associated with metastatic cancers.
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spelling pubmed-74449982020-08-25 Pseudocirrhosis in Chronic Budd Chiari Syndrome With Janus Tyrosine Kinase 2 (JAK2) Mutation Lakshmanan, Seetha Baskaran, Dhanya Onkarappa Mangala, Yashvin Toubia, Nabil Cureus Internal Medicine Budd-Chiari syndrome (BCS) occurs when there is hepatic venous outflow obstruction. Chronic BCS may result in liver cirrhosis due to long-standing obstruction and tend to present late. We present the first case of BCS secondary to Janus tyrosine kinase 2 (JAK2) mutation resulting in "pseudocirrhosis" rather than cirrhosis of the liver. Pseudocirrhosis clinically and radiologically mimics cirrhosis without the classical histopathological changes, and it is usually associated with metastatic cancers. Cureus 2020-07-23 /pmc/articles/PMC7444998/ /pubmed/32850227 http://dx.doi.org/10.7759/cureus.9355 Text en Copyright © 2020, Lakshmanan et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Lakshmanan, Seetha
Baskaran, Dhanya
Onkarappa Mangala, Yashvin
Toubia, Nabil
Pseudocirrhosis in Chronic Budd Chiari Syndrome With Janus Tyrosine Kinase 2 (JAK2) Mutation
title Pseudocirrhosis in Chronic Budd Chiari Syndrome With Janus Tyrosine Kinase 2 (JAK2) Mutation
title_full Pseudocirrhosis in Chronic Budd Chiari Syndrome With Janus Tyrosine Kinase 2 (JAK2) Mutation
title_fullStr Pseudocirrhosis in Chronic Budd Chiari Syndrome With Janus Tyrosine Kinase 2 (JAK2) Mutation
title_full_unstemmed Pseudocirrhosis in Chronic Budd Chiari Syndrome With Janus Tyrosine Kinase 2 (JAK2) Mutation
title_short Pseudocirrhosis in Chronic Budd Chiari Syndrome With Janus Tyrosine Kinase 2 (JAK2) Mutation
title_sort pseudocirrhosis in chronic budd chiari syndrome with janus tyrosine kinase 2 (jak2) mutation
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444998/
https://www.ncbi.nlm.nih.gov/pubmed/32850227
http://dx.doi.org/10.7759/cureus.9355
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