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Deletion of Stk11 and Fos in mouse BLA projection neurons alters intrinsic excitability and impairs formation of long-term aversive memory
Conditioned taste aversion (CTA) is a form of one-trial learning dependent on basolateral amygdala projection neurons (BLApn). Its underlying cellular and molecular mechanisms remain poorly understood. RNAseq from BLApn identified changes in multiple candidate learning-related transcripts including...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445010/ https://www.ncbi.nlm.nih.gov/pubmed/32779566 http://dx.doi.org/10.7554/eLife.61036 |
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author | Levitan, David Liu, Chenghao Yang, Tracy Shima, Yasuyuki Lin, Jian-You Wachutka, Joseph Marrero, Yasmin Ali Marandi Ghoddousi, Ramin da Veiga Beltrame, Eduardo Richter, Troy A Katz, Donald B Nelson, Sacha B |
author_facet | Levitan, David Liu, Chenghao Yang, Tracy Shima, Yasuyuki Lin, Jian-You Wachutka, Joseph Marrero, Yasmin Ali Marandi Ghoddousi, Ramin da Veiga Beltrame, Eduardo Richter, Troy A Katz, Donald B Nelson, Sacha B |
author_sort | Levitan, David |
collection | PubMed |
description | Conditioned taste aversion (CTA) is a form of one-trial learning dependent on basolateral amygdala projection neurons (BLApn). Its underlying cellular and molecular mechanisms remain poorly understood. RNAseq from BLApn identified changes in multiple candidate learning-related transcripts including the expected immediate early gene Fos and Stk11, a master kinase of the AMP-related kinase pathway with important roles in growth, metabolism and development, but not previously implicated in learning. Deletion of Stk11 in BLApn blocked memory prior to training, but not following it and increased neuronal excitability. Conversely, BLApn had reduced excitability following CTA. BLApn knockout of a second learning-related gene, Fos, also increased excitability and impaired learning. Independently increasing BLApn excitability chemogenetically during CTA also impaired memory. STK11 and C-FOS activation were independent of one another. These data suggest key roles for Stk11 and Fos in CTA long-term memory formation, dependent at least partly through convergent action on BLApn intrinsic excitability. |
format | Online Article Text |
id | pubmed-7445010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-74450102020-08-26 Deletion of Stk11 and Fos in mouse BLA projection neurons alters intrinsic excitability and impairs formation of long-term aversive memory Levitan, David Liu, Chenghao Yang, Tracy Shima, Yasuyuki Lin, Jian-You Wachutka, Joseph Marrero, Yasmin Ali Marandi Ghoddousi, Ramin da Veiga Beltrame, Eduardo Richter, Troy A Katz, Donald B Nelson, Sacha B eLife Neuroscience Conditioned taste aversion (CTA) is a form of one-trial learning dependent on basolateral amygdala projection neurons (BLApn). Its underlying cellular and molecular mechanisms remain poorly understood. RNAseq from BLApn identified changes in multiple candidate learning-related transcripts including the expected immediate early gene Fos and Stk11, a master kinase of the AMP-related kinase pathway with important roles in growth, metabolism and development, but not previously implicated in learning. Deletion of Stk11 in BLApn blocked memory prior to training, but not following it and increased neuronal excitability. Conversely, BLApn had reduced excitability following CTA. BLApn knockout of a second learning-related gene, Fos, also increased excitability and impaired learning. Independently increasing BLApn excitability chemogenetically during CTA also impaired memory. STK11 and C-FOS activation were independent of one another. These data suggest key roles for Stk11 and Fos in CTA long-term memory formation, dependent at least partly through convergent action on BLApn intrinsic excitability. eLife Sciences Publications, Ltd 2020-08-11 /pmc/articles/PMC7445010/ /pubmed/32779566 http://dx.doi.org/10.7554/eLife.61036 Text en © 2020, Levitan et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Levitan, David Liu, Chenghao Yang, Tracy Shima, Yasuyuki Lin, Jian-You Wachutka, Joseph Marrero, Yasmin Ali Marandi Ghoddousi, Ramin da Veiga Beltrame, Eduardo Richter, Troy A Katz, Donald B Nelson, Sacha B Deletion of Stk11 and Fos in mouse BLA projection neurons alters intrinsic excitability and impairs formation of long-term aversive memory |
title | Deletion of Stk11 and Fos in mouse BLA projection neurons alters intrinsic excitability and impairs formation of long-term aversive memory |
title_full | Deletion of Stk11 and Fos in mouse BLA projection neurons alters intrinsic excitability and impairs formation of long-term aversive memory |
title_fullStr | Deletion of Stk11 and Fos in mouse BLA projection neurons alters intrinsic excitability and impairs formation of long-term aversive memory |
title_full_unstemmed | Deletion of Stk11 and Fos in mouse BLA projection neurons alters intrinsic excitability and impairs formation of long-term aversive memory |
title_short | Deletion of Stk11 and Fos in mouse BLA projection neurons alters intrinsic excitability and impairs formation of long-term aversive memory |
title_sort | deletion of stk11 and fos in mouse bla projection neurons alters intrinsic excitability and impairs formation of long-term aversive memory |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445010/ https://www.ncbi.nlm.nih.gov/pubmed/32779566 http://dx.doi.org/10.7554/eLife.61036 |
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