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Trends in incidence of anal cancer in Austria, 1983–2016

BACKGROUND: Recent reports have noted increasing rates of anal cancer among high-income countries worldwide; however, little is known about these trends in Austria. METHODS: Data on anal cancer from 1983 to 2016 were obtained from Statistics Austria. All tumors (n = 3567) were classified into anal s...

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Autores principales: Heer, Emily, Hackl, Monika, Ferlitsch, Monika, Waldhoer, Thomas, Yang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445201/
https://www.ncbi.nlm.nih.gov/pubmed/32130523
http://dx.doi.org/10.1007/s00508-020-01622-z
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author Heer, Emily
Hackl, Monika
Ferlitsch, Monika
Waldhoer, Thomas
Yang, Lin
author_facet Heer, Emily
Hackl, Monika
Ferlitsch, Monika
Waldhoer, Thomas
Yang, Lin
author_sort Heer, Emily
collection PubMed
description BACKGROUND: Recent reports have noted increasing rates of anal cancer among high-income countries worldwide; however, little is known about these trends in Austria. METHODS: Data on anal cancer from 1983 to 2016 were obtained from Statistics Austria. All tumors (n = 3567) were classified into anal squamous cell carcinomas (ASCC), anal adenocarcinomas (AADC), and others (unspecified carcinoma and other specific carcinoma). Anal cancer incidence rates were calculated in 5‑year cycles and incidence average annual percentage change (AAPC) to evaluate trends by sex, histology and age group. RESULTS: The incidence rate of anal cancer was higher among females than males (relative risk, RR = 1.66, 95% confidence interval, CI: 1.55–1.79, p < 0.0001). From 1983 through 2016, incident anal cancer increased significantly (0.92 per 100,000 person-years to 1.85 per 100,000 person-years, AAPC = 1.93, 95% CI: 1.52 to 2.34, p < 0.0001), particularly among those 40–69 years old. From 1983 through 2016, the increasing anal cancer incidence was primarily driven by ASCC (0.47–1.20 per 100,000 person-years, AAPC = 2.23, 95% CI: 1.58 to 2.88, p < 0.0001) and others (other than ASCC and AADC, AAPC = 1.78, 95% CI: 1.01–2.55), yet stable in AADC (AAPC = 0.88, 95% CI: −0.48–2.25). CONCLUSIONS: Despite being a rare cancer in Austria, the increase in anal cancer incidence rate from 1983 to 2016 was substantial, particularly in ASCC. The observed rising trends reflect the need to investigate associated risk factors that have increased over time to inform preventive measures. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00508-020-01622-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-74452012020-08-31 Trends in incidence of anal cancer in Austria, 1983–2016 Heer, Emily Hackl, Monika Ferlitsch, Monika Waldhoer, Thomas Yang, Lin Wien Klin Wochenschr Original Article BACKGROUND: Recent reports have noted increasing rates of anal cancer among high-income countries worldwide; however, little is known about these trends in Austria. METHODS: Data on anal cancer from 1983 to 2016 were obtained from Statistics Austria. All tumors (n = 3567) were classified into anal squamous cell carcinomas (ASCC), anal adenocarcinomas (AADC), and others (unspecified carcinoma and other specific carcinoma). Anal cancer incidence rates were calculated in 5‑year cycles and incidence average annual percentage change (AAPC) to evaluate trends by sex, histology and age group. RESULTS: The incidence rate of anal cancer was higher among females than males (relative risk, RR = 1.66, 95% confidence interval, CI: 1.55–1.79, p < 0.0001). From 1983 through 2016, incident anal cancer increased significantly (0.92 per 100,000 person-years to 1.85 per 100,000 person-years, AAPC = 1.93, 95% CI: 1.52 to 2.34, p < 0.0001), particularly among those 40–69 years old. From 1983 through 2016, the increasing anal cancer incidence was primarily driven by ASCC (0.47–1.20 per 100,000 person-years, AAPC = 2.23, 95% CI: 1.58 to 2.88, p < 0.0001) and others (other than ASCC and AADC, AAPC = 1.78, 95% CI: 1.01–2.55), yet stable in AADC (AAPC = 0.88, 95% CI: −0.48–2.25). CONCLUSIONS: Despite being a rare cancer in Austria, the increase in anal cancer incidence rate from 1983 to 2016 was substantial, particularly in ASCC. The observed rising trends reflect the need to investigate associated risk factors that have increased over time to inform preventive measures. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00508-020-01622-z) contains supplementary material, which is available to authorized users. Springer Vienna 2020-03-04 2020 /pmc/articles/PMC7445201/ /pubmed/32130523 http://dx.doi.org/10.1007/s00508-020-01622-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Heer, Emily
Hackl, Monika
Ferlitsch, Monika
Waldhoer, Thomas
Yang, Lin
Trends in incidence of anal cancer in Austria, 1983–2016
title Trends in incidence of anal cancer in Austria, 1983–2016
title_full Trends in incidence of anal cancer in Austria, 1983–2016
title_fullStr Trends in incidence of anal cancer in Austria, 1983–2016
title_full_unstemmed Trends in incidence of anal cancer in Austria, 1983–2016
title_short Trends in incidence of anal cancer in Austria, 1983–2016
title_sort trends in incidence of anal cancer in austria, 1983–2016
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445201/
https://www.ncbi.nlm.nih.gov/pubmed/32130523
http://dx.doi.org/10.1007/s00508-020-01622-z
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