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Breast cancer with an intraductal component that was proven genetically to be metastasis of contralateral breast cancer: a case report

BACKGROUND: When diagnosing patients with bilateral breast cancer, it is challenging to determine the relationship between multiple breast cancer lesions at the individual patient level with certainty. CASE PRESENTATION: A 35-year-old Japanese woman was diagnosed with a left breast cancer. She was p...

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Autores principales: Shinden, Yoshiaki, Saho, Hazuki, Nomoto, Yuki, Nagata, Ayako, Minami, Koji, Nakajo, Akihiro, Akahane, Toshiaki, Hiraki, Tsubasa, Tanimoto, Akihide, Owaki, Tetsuhiro, Kijima, Yuko, Natsugoe, Shoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445210/
https://www.ncbi.nlm.nih.gov/pubmed/32833091
http://dx.doi.org/10.1186/s40792-020-00966-y
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author Shinden, Yoshiaki
Saho, Hazuki
Nomoto, Yuki
Nagata, Ayako
Minami, Koji
Nakajo, Akihiro
Akahane, Toshiaki
Hiraki, Tsubasa
Tanimoto, Akihide
Owaki, Tetsuhiro
Kijima, Yuko
Natsugoe, Shoji
author_facet Shinden, Yoshiaki
Saho, Hazuki
Nomoto, Yuki
Nagata, Ayako
Minami, Koji
Nakajo, Akihiro
Akahane, Toshiaki
Hiraki, Tsubasa
Tanimoto, Akihide
Owaki, Tetsuhiro
Kijima, Yuko
Natsugoe, Shoji
author_sort Shinden, Yoshiaki
collection PubMed
description BACKGROUND: When diagnosing patients with bilateral breast cancer, it is challenging to determine the relationship between multiple breast cancer lesions at the individual patient level with certainty. CASE PRESENTATION: A 35-year-old Japanese woman was diagnosed with a left breast cancer. She was previously diagnosed with right pT3N3M0 stage IIIC breast cancer and underwent chemotherapy with targeted therapy, radiotherapy, and endocrine therapy as adjuvant treatment after mastectomy and axillary lymph node dissection. Approximately 2 years after the first surgery, her left breast cancer was preoperatively diagnosed as a contralateral primary breast cancer, and left mastectomy and axillary lymph node dissection were performed. Histopathologically, the tumor was determined to be invasive ductal carcinoma accompanied with several intraductal components. After a second surgery, mutation analysis of her bilateral breast cancer was performed in a clinical study, which revealed that her metachronous bilateral breast tumors had the same GATA3 and CSMD1 mutations. Thus, mutation analysis strongly supported her latter left breast cancer being a metastatic lesion from the former right breast cancer. Some difficulties in diagnosing bilateral breast cancer exist when determining whether they are double primary cancers or represent contralateral breast metastasis. The existence of intraductal components is a critical piece of information for suspecting primary lesions. However, this case demonstrated that metastatic contralateral breast lesions can have intraductal components. CONCLUSION: Herein we report a genetically proven contralateral breast metastasis with some intraductal components.
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spelling pubmed-74452102020-09-02 Breast cancer with an intraductal component that was proven genetically to be metastasis of contralateral breast cancer: a case report Shinden, Yoshiaki Saho, Hazuki Nomoto, Yuki Nagata, Ayako Minami, Koji Nakajo, Akihiro Akahane, Toshiaki Hiraki, Tsubasa Tanimoto, Akihide Owaki, Tetsuhiro Kijima, Yuko Natsugoe, Shoji Surg Case Rep Case Report BACKGROUND: When diagnosing patients with bilateral breast cancer, it is challenging to determine the relationship between multiple breast cancer lesions at the individual patient level with certainty. CASE PRESENTATION: A 35-year-old Japanese woman was diagnosed with a left breast cancer. She was previously diagnosed with right pT3N3M0 stage IIIC breast cancer and underwent chemotherapy with targeted therapy, radiotherapy, and endocrine therapy as adjuvant treatment after mastectomy and axillary lymph node dissection. Approximately 2 years after the first surgery, her left breast cancer was preoperatively diagnosed as a contralateral primary breast cancer, and left mastectomy and axillary lymph node dissection were performed. Histopathologically, the tumor was determined to be invasive ductal carcinoma accompanied with several intraductal components. After a second surgery, mutation analysis of her bilateral breast cancer was performed in a clinical study, which revealed that her metachronous bilateral breast tumors had the same GATA3 and CSMD1 mutations. Thus, mutation analysis strongly supported her latter left breast cancer being a metastatic lesion from the former right breast cancer. Some difficulties in diagnosing bilateral breast cancer exist when determining whether they are double primary cancers or represent contralateral breast metastasis. The existence of intraductal components is a critical piece of information for suspecting primary lesions. However, this case demonstrated that metastatic contralateral breast lesions can have intraductal components. CONCLUSION: Herein we report a genetically proven contralateral breast metastasis with some intraductal components. Springer Berlin Heidelberg 2020-08-24 /pmc/articles/PMC7445210/ /pubmed/32833091 http://dx.doi.org/10.1186/s40792-020-00966-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Case Report
Shinden, Yoshiaki
Saho, Hazuki
Nomoto, Yuki
Nagata, Ayako
Minami, Koji
Nakajo, Akihiro
Akahane, Toshiaki
Hiraki, Tsubasa
Tanimoto, Akihide
Owaki, Tetsuhiro
Kijima, Yuko
Natsugoe, Shoji
Breast cancer with an intraductal component that was proven genetically to be metastasis of contralateral breast cancer: a case report
title Breast cancer with an intraductal component that was proven genetically to be metastasis of contralateral breast cancer: a case report
title_full Breast cancer with an intraductal component that was proven genetically to be metastasis of contralateral breast cancer: a case report
title_fullStr Breast cancer with an intraductal component that was proven genetically to be metastasis of contralateral breast cancer: a case report
title_full_unstemmed Breast cancer with an intraductal component that was proven genetically to be metastasis of contralateral breast cancer: a case report
title_short Breast cancer with an intraductal component that was proven genetically to be metastasis of contralateral breast cancer: a case report
title_sort breast cancer with an intraductal component that was proven genetically to be metastasis of contralateral breast cancer: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445210/
https://www.ncbi.nlm.nih.gov/pubmed/32833091
http://dx.doi.org/10.1186/s40792-020-00966-y
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