Preventing and treating PTSD-like memory by trauma contextualization

Post-traumatic stress disorder (PTSD) is characterized by emotional hypermnesia on which preclinical studies focus so far. While this hypermnesia relates to salient traumatic cues, partial amnesia for the traumatic context can also be observed. Here, we show in mice that contextual amnesia is causal...

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Detalles Bibliográficos
Autores principales: Al Abed, Alice Shaam, Ducourneau, Eva-Gunnel, Bouarab, Chloé, Sellami, Azza, Marighetto, Aline, Desmedt, Aline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445258/
https://www.ncbi.nlm.nih.gov/pubmed/32839437
http://dx.doi.org/10.1038/s41467-020-18002-w
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author Al Abed, Alice Shaam
Ducourneau, Eva-Gunnel
Bouarab, Chloé
Sellami, Azza
Marighetto, Aline
Desmedt, Aline
author_facet Al Abed, Alice Shaam
Ducourneau, Eva-Gunnel
Bouarab, Chloé
Sellami, Azza
Marighetto, Aline
Desmedt, Aline
author_sort Al Abed, Alice Shaam
collection PubMed
description Post-traumatic stress disorder (PTSD) is characterized by emotional hypermnesia on which preclinical studies focus so far. While this hypermnesia relates to salient traumatic cues, partial amnesia for the traumatic context can also be observed. Here, we show in mice that contextual amnesia is causally involved in PTSD-like memory formation, and that treating the amnesia by re-exposure to all trauma-related cues cures PTSD-like hypermnesia. These findings open a therapeutic perspective based on trauma contextualization and the underlying hippocampal mechanisms.
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spelling pubmed-74452582020-09-02 Preventing and treating PTSD-like memory by trauma contextualization Al Abed, Alice Shaam Ducourneau, Eva-Gunnel Bouarab, Chloé Sellami, Azza Marighetto, Aline Desmedt, Aline Nat Commun Article Post-traumatic stress disorder (PTSD) is characterized by emotional hypermnesia on which preclinical studies focus so far. While this hypermnesia relates to salient traumatic cues, partial amnesia for the traumatic context can also be observed. Here, we show in mice that contextual amnesia is causally involved in PTSD-like memory formation, and that treating the amnesia by re-exposure to all trauma-related cues cures PTSD-like hypermnesia. These findings open a therapeutic perspective based on trauma contextualization and the underlying hippocampal mechanisms. Nature Publishing Group UK 2020-08-24 /pmc/articles/PMC7445258/ /pubmed/32839437 http://dx.doi.org/10.1038/s41467-020-18002-w Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Al Abed, Alice Shaam
Ducourneau, Eva-Gunnel
Bouarab, Chloé
Sellami, Azza
Marighetto, Aline
Desmedt, Aline
Preventing and treating PTSD-like memory by trauma contextualization
title Preventing and treating PTSD-like memory by trauma contextualization
title_full Preventing and treating PTSD-like memory by trauma contextualization
title_fullStr Preventing and treating PTSD-like memory by trauma contextualization
title_full_unstemmed Preventing and treating PTSD-like memory by trauma contextualization
title_short Preventing and treating PTSD-like memory by trauma contextualization
title_sort preventing and treating ptsd-like memory by trauma contextualization
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445258/
https://www.ncbi.nlm.nih.gov/pubmed/32839437
http://dx.doi.org/10.1038/s41467-020-18002-w
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