Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers

The design of subunit vaccines requires new adjuvant systems. We designed and synthesized new lipopeptides (cysteine-based) of low molecular weight with different hydrophobic chains that dimerize becoming gemini lipopeptides. They were characterized and their adjuvant capacity was tested in mice by...

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Detalles Bibliográficos
Autores principales: Grippo, Lucía Daniela, Reidel, Ivana Gabriela, García, María Inés, Streu, Alexis, Müller, Diana María, Veaute, Carolina Melania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Vaccine Society 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445326/
https://www.ncbi.nlm.nih.gov/pubmed/32864372
http://dx.doi.org/10.7774/cevr.2020.9.2.159
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author Grippo, Lucía Daniela
Reidel, Ivana Gabriela
García, María Inés
Streu, Alexis
Müller, Diana María
Veaute, Carolina Melania
author_facet Grippo, Lucía Daniela
Reidel, Ivana Gabriela
García, María Inés
Streu, Alexis
Müller, Diana María
Veaute, Carolina Melania
author_sort Grippo, Lucía Daniela
collection PubMed
description The design of subunit vaccines requires new adjuvant systems. We designed and synthesized new lipopeptides (cysteine-based) of low molecular weight with different hydrophobic chains that dimerize becoming gemini lipopeptides. They were characterized and their adjuvant capacity was tested in mice by the inoculation of a protein antigen formulated with the lipopeptides, with and without the addition of CpG-oligodeoxynucleotides. Formulations were able to induce an immune response and produced no adverse effects. An adjuvant ability is described for the first time for this type of molecules.
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spelling pubmed-74453262020-08-27 Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers Grippo, Lucía Daniela Reidel, Ivana Gabriela García, María Inés Streu, Alexis Müller, Diana María Veaute, Carolina Melania Clin Exp Vaccine Res Brief Communication The design of subunit vaccines requires new adjuvant systems. We designed and synthesized new lipopeptides (cysteine-based) of low molecular weight with different hydrophobic chains that dimerize becoming gemini lipopeptides. They were characterized and their adjuvant capacity was tested in mice by the inoculation of a protein antigen formulated with the lipopeptides, with and without the addition of CpG-oligodeoxynucleotides. Formulations were able to induce an immune response and produced no adverse effects. An adjuvant ability is described for the first time for this type of molecules. The Korean Vaccine Society 2020-07 2020-07-31 /pmc/articles/PMC7445326/ /pubmed/32864372 http://dx.doi.org/10.7774/cevr.2020.9.2.159 Text en © Korean Vaccine Society. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Grippo, Lucía Daniela
Reidel, Ivana Gabriela
García, María Inés
Streu, Alexis
Müller, Diana María
Veaute, Carolina Melania
Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers
title Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers
title_full Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers
title_fullStr Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers
title_full_unstemmed Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers
title_short Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers
title_sort gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445326/
https://www.ncbi.nlm.nih.gov/pubmed/32864372
http://dx.doi.org/10.7774/cevr.2020.9.2.159
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