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KIF5B-EGFR Fusion: A Novel EGFR Mutation in Lung Adenocarcinoma

With the rapid development of detection methods, next-generation sequencing (NGS) technology as a new technology, some novel epidermal growth factor receptor (EGFR) gene fusions comprising the EGFR linked to various fusion partners, most commonly RAD51, are detected in the non-small cell lung cancer...

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Autores principales: Xu, Hui, Shao, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445495/
https://www.ncbi.nlm.nih.gov/pubmed/32903808
http://dx.doi.org/10.2147/OTT.S263994
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author Xu, Hui
Shao, Chuan
author_facet Xu, Hui
Shao, Chuan
author_sort Xu, Hui
collection PubMed
description With the rapid development of detection methods, next-generation sequencing (NGS) technology as a new technology, some novel epidermal growth factor receptor (EGFR) gene fusions comprising the EGFR linked to various fusion partners, most commonly RAD51, are detected in the non-small cell lung cancer (NSCLC). We described a case of an unreported kinesin family member 5B (KIF5B)-EGFR in NSCLC and the efficacy of EGFR tyrosine kinase inhibitors (TKIs) to this specific fusion. Considering this rare EGFR fusion and remarkable response to EGFR-TKI, we should realize the importance of these rare EGFR fusions, the advances in diagnostic techniques and personalized care for lung cancer patients.
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spelling pubmed-74454952020-09-04 KIF5B-EGFR Fusion: A Novel EGFR Mutation in Lung Adenocarcinoma Xu, Hui Shao, Chuan Onco Targets Ther Case Report With the rapid development of detection methods, next-generation sequencing (NGS) technology as a new technology, some novel epidermal growth factor receptor (EGFR) gene fusions comprising the EGFR linked to various fusion partners, most commonly RAD51, are detected in the non-small cell lung cancer (NSCLC). We described a case of an unreported kinesin family member 5B (KIF5B)-EGFR in NSCLC and the efficacy of EGFR tyrosine kinase inhibitors (TKIs) to this specific fusion. Considering this rare EGFR fusion and remarkable response to EGFR-TKI, we should realize the importance of these rare EGFR fusions, the advances in diagnostic techniques and personalized care for lung cancer patients. Dove 2020-08-20 /pmc/articles/PMC7445495/ /pubmed/32903808 http://dx.doi.org/10.2147/OTT.S263994 Text en © 2020 Xu and Shao. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Xu, Hui
Shao, Chuan
KIF5B-EGFR Fusion: A Novel EGFR Mutation in Lung Adenocarcinoma
title KIF5B-EGFR Fusion: A Novel EGFR Mutation in Lung Adenocarcinoma
title_full KIF5B-EGFR Fusion: A Novel EGFR Mutation in Lung Adenocarcinoma
title_fullStr KIF5B-EGFR Fusion: A Novel EGFR Mutation in Lung Adenocarcinoma
title_full_unstemmed KIF5B-EGFR Fusion: A Novel EGFR Mutation in Lung Adenocarcinoma
title_short KIF5B-EGFR Fusion: A Novel EGFR Mutation in Lung Adenocarcinoma
title_sort kif5b-egfr fusion: a novel egfr mutation in lung adenocarcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445495/
https://www.ncbi.nlm.nih.gov/pubmed/32903808
http://dx.doi.org/10.2147/OTT.S263994
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