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Methotrexate-Induced Pancytopenia and Mucositis Caused by Medication Error

The use of methotrexate in routine clinical practice is becoming more common among specialties such as rheumatology, dermatology, oncology and obstetrics. General clinicians are increasingly encountering patients on this drug. Though it has a high safety profile, there is a recognised risk of acute...

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Detalles Bibliográficos
Autores principales: Amissah-Arthur, Maame-Boatemaa, Baah, Winifred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ghana Medical Association 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445697/
https://www.ncbi.nlm.nih.gov/pubmed/32863415
http://dx.doi.org/10.4314/gmj.v54i1.10
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author Amissah-Arthur, Maame-Boatemaa
Baah, Winifred
author_facet Amissah-Arthur, Maame-Boatemaa
Baah, Winifred
author_sort Amissah-Arthur, Maame-Boatemaa
collection PubMed
description The use of methotrexate in routine clinical practice is becoming more common among specialties such as rheumatology, dermatology, oncology and obstetrics. General clinicians are increasingly encountering patients on this drug. Though it has a high safety profile, there is a recognised risk of acute toxicity or long-term complications associated with its use, which can be worsened by several factors such as advanced age, moderate to severe renal impairment, low folate level and/or inadequate folate supplementation, hypoalbuminaemia, polypharmacy causing drug-drug interactions and wrongful administration. We present a case of a 45-year old woman with rheumatoid arthritis who presented with acute pancytopaenia and mucositis due to methotrexate toxicity. We highlight its peculiar dosing regimen to minimise prescribing errors. FUNDING: None
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spelling pubmed-74456972020-08-27 Methotrexate-Induced Pancytopenia and Mucositis Caused by Medication Error Amissah-Arthur, Maame-Boatemaa Baah, Winifred Ghana Med J Case Report The use of methotrexate in routine clinical practice is becoming more common among specialties such as rheumatology, dermatology, oncology and obstetrics. General clinicians are increasingly encountering patients on this drug. Though it has a high safety profile, there is a recognised risk of acute toxicity or long-term complications associated with its use, which can be worsened by several factors such as advanced age, moderate to severe renal impairment, low folate level and/or inadequate folate supplementation, hypoalbuminaemia, polypharmacy causing drug-drug interactions and wrongful administration. We present a case of a 45-year old woman with rheumatoid arthritis who presented with acute pancytopaenia and mucositis due to methotrexate toxicity. We highlight its peculiar dosing regimen to minimise prescribing errors. FUNDING: None Ghana Medical Association 2020-03 /pmc/articles/PMC7445697/ /pubmed/32863415 http://dx.doi.org/10.4314/gmj.v54i1.10 Text en Copyright © The Author(s). This is an Open Access article under the CC BY license.
spellingShingle Case Report
Amissah-Arthur, Maame-Boatemaa
Baah, Winifred
Methotrexate-Induced Pancytopenia and Mucositis Caused by Medication Error
title Methotrexate-Induced Pancytopenia and Mucositis Caused by Medication Error
title_full Methotrexate-Induced Pancytopenia and Mucositis Caused by Medication Error
title_fullStr Methotrexate-Induced Pancytopenia and Mucositis Caused by Medication Error
title_full_unstemmed Methotrexate-Induced Pancytopenia and Mucositis Caused by Medication Error
title_short Methotrexate-Induced Pancytopenia and Mucositis Caused by Medication Error
title_sort methotrexate-induced pancytopenia and mucositis caused by medication error
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445697/
https://www.ncbi.nlm.nih.gov/pubmed/32863415
http://dx.doi.org/10.4314/gmj.v54i1.10
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