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Methotrexate-Induced Pancytopenia and Mucositis Caused by Medication Error
The use of methotrexate in routine clinical practice is becoming more common among specialties such as rheumatology, dermatology, oncology and obstetrics. General clinicians are increasingly encountering patients on this drug. Though it has a high safety profile, there is a recognised risk of acute...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ghana Medical Association
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445697/ https://www.ncbi.nlm.nih.gov/pubmed/32863415 http://dx.doi.org/10.4314/gmj.v54i1.10 |
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author | Amissah-Arthur, Maame-Boatemaa Baah, Winifred |
author_facet | Amissah-Arthur, Maame-Boatemaa Baah, Winifred |
author_sort | Amissah-Arthur, Maame-Boatemaa |
collection | PubMed |
description | The use of methotrexate in routine clinical practice is becoming more common among specialties such as rheumatology, dermatology, oncology and obstetrics. General clinicians are increasingly encountering patients on this drug. Though it has a high safety profile, there is a recognised risk of acute toxicity or long-term complications associated with its use, which can be worsened by several factors such as advanced age, moderate to severe renal impairment, low folate level and/or inadequate folate supplementation, hypoalbuminaemia, polypharmacy causing drug-drug interactions and wrongful administration. We present a case of a 45-year old woman with rheumatoid arthritis who presented with acute pancytopaenia and mucositis due to methotrexate toxicity. We highlight its peculiar dosing regimen to minimise prescribing errors. FUNDING: None |
format | Online Article Text |
id | pubmed-7445697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Ghana Medical Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-74456972020-08-27 Methotrexate-Induced Pancytopenia and Mucositis Caused by Medication Error Amissah-Arthur, Maame-Boatemaa Baah, Winifred Ghana Med J Case Report The use of methotrexate in routine clinical practice is becoming more common among specialties such as rheumatology, dermatology, oncology and obstetrics. General clinicians are increasingly encountering patients on this drug. Though it has a high safety profile, there is a recognised risk of acute toxicity or long-term complications associated with its use, which can be worsened by several factors such as advanced age, moderate to severe renal impairment, low folate level and/or inadequate folate supplementation, hypoalbuminaemia, polypharmacy causing drug-drug interactions and wrongful administration. We present a case of a 45-year old woman with rheumatoid arthritis who presented with acute pancytopaenia and mucositis due to methotrexate toxicity. We highlight its peculiar dosing regimen to minimise prescribing errors. FUNDING: None Ghana Medical Association 2020-03 /pmc/articles/PMC7445697/ /pubmed/32863415 http://dx.doi.org/10.4314/gmj.v54i1.10 Text en Copyright © The Author(s). This is an Open Access article under the CC BY license. |
spellingShingle | Case Report Amissah-Arthur, Maame-Boatemaa Baah, Winifred Methotrexate-Induced Pancytopenia and Mucositis Caused by Medication Error |
title | Methotrexate-Induced Pancytopenia and Mucositis Caused by Medication Error |
title_full | Methotrexate-Induced Pancytopenia and Mucositis Caused by Medication Error |
title_fullStr | Methotrexate-Induced Pancytopenia and Mucositis Caused by Medication Error |
title_full_unstemmed | Methotrexate-Induced Pancytopenia and Mucositis Caused by Medication Error |
title_short | Methotrexate-Induced Pancytopenia and Mucositis Caused by Medication Error |
title_sort | methotrexate-induced pancytopenia and mucositis caused by medication error |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445697/ https://www.ncbi.nlm.nih.gov/pubmed/32863415 http://dx.doi.org/10.4314/gmj.v54i1.10 |
work_keys_str_mv | AT amissaharthurmaameboatemaa methotrexateinducedpancytopeniaandmucositiscausedbymedicationerror AT baahwinifred methotrexateinducedpancytopeniaandmucositiscausedbymedicationerror |