Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model

[Image: see text] Polymorphisms in the region of the calmodulin-dependent kinase isoform D (CaMK1D) gene are associated with increased incidence of diabetes, with the most common polymorphism resulting in increased recognition by transcription factors and increased protein expression. While reducing...

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Autores principales: Fromont, Christophe, Atzori, Alessio, Kaur, Divneet, Hashmi, Lubna, Greco, Graziella, Cabanillas, Alejandro, Nguyen, Huy Van, Jones, D. Heulyn, Garzón, Miguel, Varela, Ana, Stevenson, Brett, Iacobini, Greg P., Lenoir, Marc, Rajesh, Sundaresan, Box, Clare, Kumar, Jitendra, Grant, Paige, Novitskaya, Vera, Morgan, Juliet, Sorrell, Fiona J., Redondo, Clara, Kramer, Andreas, Harris, C. John, Leighton, Brendan, Vickers, Steven P., Cheetham, Sharon C., Kenyon, Colin, Grabowska, Anna M., Overduin, Michael, Berditchevski, Fedor, Weston, Chris J., Knapp, Stefan, Fischer, Peter M., Butterworth, Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445743/
https://www.ncbi.nlm.nih.gov/pubmed/32433887
http://dx.doi.org/10.1021/acs.jmedchem.9b01803

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