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Effectiveness of Visual vs. Acoustic Closed-Loop Stimulation on EEG Power Density during NREM Sleep in Humans

The aim of the study was to investigate whether visual stimuli have the same potency to increase electroencephalography (EEG) delta wave power density during non-rapid eye movement (NREM) sleep as do auditory stimuli that may be practical in the treatment of some sleep disturbances. Nine healthy sub...

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Autores principales: Danilenko, Konstantin V., Kobelev, Evgenii, Yarosh, Sergei V., Khazankin, Grigorii R., Brack, Ivan V., Miroshnikova, Polina V., Aftanas, Lyubomir I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445827/
https://www.ncbi.nlm.nih.gov/pubmed/33089198
http://dx.doi.org/10.3390/clockssleep2020014
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author Danilenko, Konstantin V.
Kobelev, Evgenii
Yarosh, Sergei V.
Khazankin, Grigorii R.
Brack, Ivan V.
Miroshnikova, Polina V.
Aftanas, Lyubomir I.
author_facet Danilenko, Konstantin V.
Kobelev, Evgenii
Yarosh, Sergei V.
Khazankin, Grigorii R.
Brack, Ivan V.
Miroshnikova, Polina V.
Aftanas, Lyubomir I.
author_sort Danilenko, Konstantin V.
collection PubMed
description The aim of the study was to investigate whether visual stimuli have the same potency to increase electroencephalography (EEG) delta wave power density during non-rapid eye movement (NREM) sleep as do auditory stimuli that may be practical in the treatment of some sleep disturbances. Nine healthy subjects underwent two polysomnography sessions—adaptation and experimental—with EEG electrodes positioned at Fz–Cz. Individually adjusted auditory (pink noise) and visual (light-emitting diode (LED) red light) paired 50-ms signals were automatically presented via headphones/eye mask during NREM sleep, shortly (0.75–0.90 s) after the EEG wave descended below a preset amplitude threshold (closed-loop in-phase stimulation). The alternately repeated 30-s epochs with stimuli of a given modality (light, sound, or light and sound simultaneously) were preceded and followed by 30-s epochs without stimulation. The number of artifact-free 1.5-min cycles taken in the analysis was such that the cycles with stimuli of different modalities were matched by number of stimuli presented. Acoustic stimuli caused an increase (p < 0.01) of EEG power density in the frequency band 0.5–3.0 Hz (slow waves); the values reverted to baseline at post-stimuli epochs. Light stimuli did not influence EEG slow wave power density (p > 0.01) and did not add to the acoustic stimuli effects. Thus, dim red light presented in a closed-loop in-phase fashion did not influence EEG power density during nocturnal sleep.
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spelling pubmed-74458272020-10-20 Effectiveness of Visual vs. Acoustic Closed-Loop Stimulation on EEG Power Density during NREM Sleep in Humans Danilenko, Konstantin V. Kobelev, Evgenii Yarosh, Sergei V. Khazankin, Grigorii R. Brack, Ivan V. Miroshnikova, Polina V. Aftanas, Lyubomir I. Clocks Sleep Article The aim of the study was to investigate whether visual stimuli have the same potency to increase electroencephalography (EEG) delta wave power density during non-rapid eye movement (NREM) sleep as do auditory stimuli that may be practical in the treatment of some sleep disturbances. Nine healthy subjects underwent two polysomnography sessions—adaptation and experimental—with EEG electrodes positioned at Fz–Cz. Individually adjusted auditory (pink noise) and visual (light-emitting diode (LED) red light) paired 50-ms signals were automatically presented via headphones/eye mask during NREM sleep, shortly (0.75–0.90 s) after the EEG wave descended below a preset amplitude threshold (closed-loop in-phase stimulation). The alternately repeated 30-s epochs with stimuli of a given modality (light, sound, or light and sound simultaneously) were preceded and followed by 30-s epochs without stimulation. The number of artifact-free 1.5-min cycles taken in the analysis was such that the cycles with stimuli of different modalities were matched by number of stimuli presented. Acoustic stimuli caused an increase (p < 0.01) of EEG power density in the frequency band 0.5–3.0 Hz (slow waves); the values reverted to baseline at post-stimuli epochs. Light stimuli did not influence EEG slow wave power density (p > 0.01) and did not add to the acoustic stimuli effects. Thus, dim red light presented in a closed-loop in-phase fashion did not influence EEG power density during nocturnal sleep. MDPI 2020-04-30 /pmc/articles/PMC7445827/ /pubmed/33089198 http://dx.doi.org/10.3390/clockssleep2020014 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Danilenko, Konstantin V.
Kobelev, Evgenii
Yarosh, Sergei V.
Khazankin, Grigorii R.
Brack, Ivan V.
Miroshnikova, Polina V.
Aftanas, Lyubomir I.
Effectiveness of Visual vs. Acoustic Closed-Loop Stimulation on EEG Power Density during NREM Sleep in Humans
title Effectiveness of Visual vs. Acoustic Closed-Loop Stimulation on EEG Power Density during NREM Sleep in Humans
title_full Effectiveness of Visual vs. Acoustic Closed-Loop Stimulation on EEG Power Density during NREM Sleep in Humans
title_fullStr Effectiveness of Visual vs. Acoustic Closed-Loop Stimulation on EEG Power Density during NREM Sleep in Humans
title_full_unstemmed Effectiveness of Visual vs. Acoustic Closed-Loop Stimulation on EEG Power Density during NREM Sleep in Humans
title_short Effectiveness of Visual vs. Acoustic Closed-Loop Stimulation on EEG Power Density during NREM Sleep in Humans
title_sort effectiveness of visual vs. acoustic closed-loop stimulation on eeg power density during nrem sleep in humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445827/
https://www.ncbi.nlm.nih.gov/pubmed/33089198
http://dx.doi.org/10.3390/clockssleep2020014
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