Cargando…

Evidence That Homeostatic Sleep Regulation Depends on Ambient Lighting Conditions during Wakefulness

We examined whether ambient lighting conditions during extended wakefulness modulate the homeostatic response to sleep loss as indexed by. slow wave sleep (SWS) and electroencephalographic (EEG) slow-wave activity (SWA) in healthy young and older volunteers. Thirty-eight young and older participants...

Descripción completa

Detalles Bibliográficos
Autores principales: Cajochen, Christian, Reichert, Carolin, Maire, Micheline, Schlangen, Luc J. M., Schmidt, Christina, Viola, Antoine U., Gabel, Virginie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445844/
https://www.ncbi.nlm.nih.gov/pubmed/33089184
http://dx.doi.org/10.3390/clockssleep1040040
_version_ 1783574062396604416
author Cajochen, Christian
Reichert, Carolin
Maire, Micheline
Schlangen, Luc J. M.
Schmidt, Christina
Viola, Antoine U.
Gabel, Virginie
author_facet Cajochen, Christian
Reichert, Carolin
Maire, Micheline
Schlangen, Luc J. M.
Schmidt, Christina
Viola, Antoine U.
Gabel, Virginie
author_sort Cajochen, Christian
collection PubMed
description We examined whether ambient lighting conditions during extended wakefulness modulate the homeostatic response to sleep loss as indexed by. slow wave sleep (SWS) and electroencephalographic (EEG) slow-wave activity (SWA) in healthy young and older volunteers. Thirty-eight young and older participants underwent 40 hours of extended wakefulness [i.e., sleep deprivation (SD)] once under dim light (DL: 8 lux, 2800 K), and once under either white light (WL: 250 lux, 2800 K) or blue-enriched white light (BL: 250 lux, 9000 K) exposure. Subjective sleepiness was assessed hourly and polysomnography was quantified during the baseline night prior to the 40-h SD and during the subsequent recovery night. Both the young and older participants responded with a higher homeostatic sleep response to 40-h SD after WL and BL than after DL. This was indexed by a significantly faster intra-night accumulation of SWS and a significantly higher response in relative EEG SWA during the recovery night after WL and BL than after DL for both age groups. No significant differences were observed between the WL and BL condition for these two particular SWS and SWA measures. Subjective sleepiness ratings during the 40-h SD were significantly reduced under both WL and BL compared to DL, but were not significantly associated with markers of sleep homeostasis in both age groups. Our data indicate that not only the duration of prior wakefulness, but also the experienced illuminance during wakefulness affects homeostatic sleep regulation in humans. Thus, working extended hours under low illuminance may negatively impact subsequent sleep intensity in humans.
format Online
Article
Text
id pubmed-7445844
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74458442020-10-20 Evidence That Homeostatic Sleep Regulation Depends on Ambient Lighting Conditions during Wakefulness Cajochen, Christian Reichert, Carolin Maire, Micheline Schlangen, Luc J. M. Schmidt, Christina Viola, Antoine U. Gabel, Virginie Clocks Sleep Article We examined whether ambient lighting conditions during extended wakefulness modulate the homeostatic response to sleep loss as indexed by. slow wave sleep (SWS) and electroencephalographic (EEG) slow-wave activity (SWA) in healthy young and older volunteers. Thirty-eight young and older participants underwent 40 hours of extended wakefulness [i.e., sleep deprivation (SD)] once under dim light (DL: 8 lux, 2800 K), and once under either white light (WL: 250 lux, 2800 K) or blue-enriched white light (BL: 250 lux, 9000 K) exposure. Subjective sleepiness was assessed hourly and polysomnography was quantified during the baseline night prior to the 40-h SD and during the subsequent recovery night. Both the young and older participants responded with a higher homeostatic sleep response to 40-h SD after WL and BL than after DL. This was indexed by a significantly faster intra-night accumulation of SWS and a significantly higher response in relative EEG SWA during the recovery night after WL and BL than after DL for both age groups. No significant differences were observed between the WL and BL condition for these two particular SWS and SWA measures. Subjective sleepiness ratings during the 40-h SD were significantly reduced under both WL and BL compared to DL, but were not significantly associated with markers of sleep homeostasis in both age groups. Our data indicate that not only the duration of prior wakefulness, but also the experienced illuminance during wakefulness affects homeostatic sleep regulation in humans. Thus, working extended hours under low illuminance may negatively impact subsequent sleep intensity in humans. MDPI 2019-12-11 /pmc/articles/PMC7445844/ /pubmed/33089184 http://dx.doi.org/10.3390/clockssleep1040040 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cajochen, Christian
Reichert, Carolin
Maire, Micheline
Schlangen, Luc J. M.
Schmidt, Christina
Viola, Antoine U.
Gabel, Virginie
Evidence That Homeostatic Sleep Regulation Depends on Ambient Lighting Conditions during Wakefulness
title Evidence That Homeostatic Sleep Regulation Depends on Ambient Lighting Conditions during Wakefulness
title_full Evidence That Homeostatic Sleep Regulation Depends on Ambient Lighting Conditions during Wakefulness
title_fullStr Evidence That Homeostatic Sleep Regulation Depends on Ambient Lighting Conditions during Wakefulness
title_full_unstemmed Evidence That Homeostatic Sleep Regulation Depends on Ambient Lighting Conditions during Wakefulness
title_short Evidence That Homeostatic Sleep Regulation Depends on Ambient Lighting Conditions during Wakefulness
title_sort evidence that homeostatic sleep regulation depends on ambient lighting conditions during wakefulness
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445844/
https://www.ncbi.nlm.nih.gov/pubmed/33089184
http://dx.doi.org/10.3390/clockssleep1040040
work_keys_str_mv AT cajochenchristian evidencethathomeostaticsleepregulationdependsonambientlightingconditionsduringwakefulness
AT reichertcarolin evidencethathomeostaticsleepregulationdependsonambientlightingconditionsduringwakefulness
AT mairemicheline evidencethathomeostaticsleepregulationdependsonambientlightingconditionsduringwakefulness
AT schlangenlucjm evidencethathomeostaticsleepregulationdependsonambientlightingconditionsduringwakefulness
AT schmidtchristina evidencethathomeostaticsleepregulationdependsonambientlightingconditionsduringwakefulness
AT violaantoineu evidencethathomeostaticsleepregulationdependsonambientlightingconditionsduringwakefulness
AT gabelvirginie evidencethathomeostaticsleepregulationdependsonambientlightingconditionsduringwakefulness