Beneficial Effects of Soluble Guanylyl Cyclase Stimulation and Activation in Sickle Cell Disease Are Amplified by Hydroxyurea: In Vitro and In Vivo Studies

The complex pathophysiology of sickle cell anemia (SCA) involves intravascular hemolytic processes and recurrent vaso-occlusion, driven by chronic vascular inflammation, which result in the disease’s severe clinical complications, including recurrent painful vaso-occlusive episodes. Hydroxyurea, the...

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Detalles Bibliográficos
Autores principales: Ferreira, W.A., Chweih, H., Lanaro, C., Almeida, C.B., Brito, P.L., Gotardo, E.M.F., Torres, L., Miguel, L.I., Franco-Penteado, C.F., Leonardo, F.C., Garcia, F., Saad, S.T.O., Frenette, P.S., Brockschnieder, D., Costa, F.F., Stasch, J.P., Sandner, P., Conran, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2020
Materias:
Drug Discovery and Translational Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445859/
https://www.ncbi.nlm.nih.gov/pubmed/32631869
http://dx.doi.org/10.1124/jpet.119.264606

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