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New somatic TERT promoter variants enhance the Telomerase activity in Glioblastoma

The catalytic activity of human Telomerase Reverse Transcriptase (TERT) compensates for the loss of telomere length, eroded during each cell cycle, to ensure a correct division of stem and germinal cells. In human tumors, ectopic TERT reactivation, most frequently due to hotspot mutations in the pro...

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Detalles Bibliográficos
Autores principales:	Pierini, Tiziana, Nardelli, Carlotta, Lema Fernandez, Anair Graciela, Pierini, Valentina, Pellanera, Fabrizia, Nofrini, Valeria, Gorello, Paolo, Moretti, Martina, Arniani, Silvia, Roti, Giovanni, Giovenali, Paolo, Lupattelli, Marco, Metro, Giulio, Molica, Carmen, Castrioto, Corrado, Corinaldesi, Rodolfo, Laurenti, Maria Elena, Ascani, Stefano, Mecucci, Cristina, La Starza, Roberta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Case Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445914/ https://www.ncbi.nlm.nih.gov/pubmed/32843091 http://dx.doi.org/10.1186/s40478-020-01022-4

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