Cyberknife, Helical Tomotherapy and Rapid Arc SIB-SBRT Treatment Plan Comparison for Carcinoma Prostate

BACKGROUND: This study was conducted to dosimetrically compare plan quality of Simultaneous Integrated Boost – Stereotactic Body Radiotherapy (SIB-SBRT) generated for different techniques such as Cyberknife (CK), Helical Tomotherapy (HT) and RapidArc (RA) for carcinoma prostate with same treatment margins. MATERIALS AND METHODS: SIB-SBRT plans were generated for CK, HT and RA for thirteen CT data sets. The dose prescription was 45Gy in 5 fractions to GTV45 and 37.5Gy in 5 fractions to PTV37.5. The plan quality evaluation of the three techniques was done by comparing the DVH parameters, conformity index (CI) and gradient index (GI). For OAR’s mean, maximum dose and dose volumes were compared for bladder, rectum and bilateral femoral heads. The number of Monitor Units (MU) delivered and Beam-on time (BOT) were also compared. RESULTS: D(2%), D(50%) and D(Mean) to GTV45 was significantly higher in the CK compared to HT and RA (CK vs HT: p values, <0.001, 0.002 and 0.003; CK vs RA: p values, 0.001, 0.004 and 0.004) respectively. RA gives a better gradient index compared to CK and HT. Conformity indices of the RA plans were better than the CK plans (P<0.001). Normal tissue and integral dose delivered to the patient in HT and CK were found to be significantly higher than RA. The average number of MU’s and BOT were significantly higher in CK (p<0.001). CONCLUSION: Using the same treatment margins and dose constraints, RA achieved better target dose distribution and sparing of critical structures compared to CK and HT. RA seemed to be the optimal planning technique for SIB-SBRT treatment of carcinoma prostate.