β-catenin represses miR455-3p to stimulate m6A modification of HSF1 mRNA and promote its translation in colorectal cancer

BACKGROUND: Heat shock transcription factor1 (HSF1) was overexpressed to promote glutaminolysis and activate mTOR in colorectal cancer (CRC). Here, we investigated the mechanism for cancer-specific overexpression of HSF1. METHODS: HSF1 expression was analyzed by chromatin immunoprecipitation, qRT-PC...

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Detalles Bibliográficos
Autores principales: Song, Ping, Feng, Lifeng, Li, Jiaqiu, Dai, Dongjun, Zhu, Liyuan, Wang, Chaoqun, Li, Jingyi, Li, Ling, Zhou, Qiyin, Shi, Rongkai, Wang, Xian, Jin, Hongchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446108/
https://www.ncbi.nlm.nih.gov/pubmed/32838807
http://dx.doi.org/10.1186/s12943-020-01244-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446108/
https://www.ncbi.nlm.nih.gov/pubmed/32838807
http://dx.doi.org/10.1186/s12943-020-01244-z

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