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Endothelial activation and stress index (EASIX) is a reliable predictor for overall survival in patients with multiple myeloma

BACKGROUND: Recently, the endothelial Activation and Stress Index (EASIX) score has been reported to predict overall survival (OS) after allogeneic stem cell transplantation. This study evaluated the prognostic role of EASIX score in patients with newly diagnosed multiple myeloma (MM). METHODS: This...

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Autores principales: Song, Ga-Young, Jung, Sung-Hoon, Kim, Kihyun, Kim, Seok Jin, Yoon, Sang Eun, Lee, Ho Sup, Kim, Mihee, Ahn, Seo-Yeon, Ahn, Jae-Sook, Yang, Deok-Hwan, Kim, Hyeoung-Joon, Lee, Je-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446202/
https://www.ncbi.nlm.nih.gov/pubmed/32831058
http://dx.doi.org/10.1186/s12885-020-07317-y
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author Song, Ga-Young
Jung, Sung-Hoon
Kim, Kihyun
Kim, Seok Jin
Yoon, Sang Eun
Lee, Ho Sup
Kim, Mihee
Ahn, Seo-Yeon
Ahn, Jae-Sook
Yang, Deok-Hwan
Kim, Hyeoung-Joon
Lee, Je-Jung
author_facet Song, Ga-Young
Jung, Sung-Hoon
Kim, Kihyun
Kim, Seok Jin
Yoon, Sang Eun
Lee, Ho Sup
Kim, Mihee
Ahn, Seo-Yeon
Ahn, Jae-Sook
Yang, Deok-Hwan
Kim, Hyeoung-Joon
Lee, Je-Jung
author_sort Song, Ga-Young
collection PubMed
description BACKGROUND: Recently, the endothelial Activation and Stress Index (EASIX) score has been reported to predict overall survival (OS) after allogeneic stem cell transplantation. This study evaluated the prognostic role of EASIX score in patients with newly diagnosed multiple myeloma (MM). METHODS: This retrospective study analyzed the records of 1177 patients with newly diagnosed MM between February 2003 and December 2017 from three institutions in the Republic of Korea. Serum lactate dehydrogenase (LDH), creatinine, and platelet count at diagnosis were measured in all included patients. EASIX scores were calculated using the formula-LDH (U/L) × Creatinine (mg/dL) / platelet count (10(9)/L) and were evaluated based on log2 transformed values. RESULTS: The median age of patients was 63 years (range, 22–92), and 495 patients (42.1%) underwent autologous stem cell transplantation (ASCT). The median log2 EASIX score at diagnosis was 1.1 (IQR 0.3–2.3). Using maximally selected log-rank statistics, the optimal EASIX cutoff value for OS was 1.87 on the log2 scale (95% CI 0.562–0.619, p < 0.001). After median follow-up for 50.0 months (range, 0.3–184.1), the median OS was 58.2 months (95% CI 53.644–62.674). Overall, 372 patients (31.6%) showed high EASIX scores at diagnosis, and had significantly inferior OS compared to those with low EASIX (log2 EASIX ≤1.87) (39.1 months vs. 67.2 months, p < 0.001). In multivariate Cox analysis, high EASIX was significantly associated with poor OS (HR 1.444, 95% CI 1.170–1.780, p = 0.001). In the subgroup analysis of patients who underwent ASCT, patients with high EASIX showed significantly inferior OS compared to those with low EASIX (52.8 months vs. 87.0 months, p < 0.001). In addition, in each group of ISS I, II, and III, high EASIX was associated with significantly inferior OS (ISS 1, 45.2 months vs. 76.0 months, p = 0.001; ISS 2, 42.3 months vs. 66.5 months, p = 0.002; ISS 3, 36.8 months vs. 55.1 months, p = 0.001). CONCLUSION: EASIX score at diagnosis is a simple and strong predictor for OS in patients with newly diagnosed MM.
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spelling pubmed-74462022020-08-26 Endothelial activation and stress index (EASIX) is a reliable predictor for overall survival in patients with multiple myeloma Song, Ga-Young Jung, Sung-Hoon Kim, Kihyun Kim, Seok Jin Yoon, Sang Eun Lee, Ho Sup Kim, Mihee Ahn, Seo-Yeon Ahn, Jae-Sook Yang, Deok-Hwan Kim, Hyeoung-Joon Lee, Je-Jung BMC Cancer Research Article BACKGROUND: Recently, the endothelial Activation and Stress Index (EASIX) score has been reported to predict overall survival (OS) after allogeneic stem cell transplantation. This study evaluated the prognostic role of EASIX score in patients with newly diagnosed multiple myeloma (MM). METHODS: This retrospective study analyzed the records of 1177 patients with newly diagnosed MM between February 2003 and December 2017 from three institutions in the Republic of Korea. Serum lactate dehydrogenase (LDH), creatinine, and platelet count at diagnosis were measured in all included patients. EASIX scores were calculated using the formula-LDH (U/L) × Creatinine (mg/dL) / platelet count (10(9)/L) and were evaluated based on log2 transformed values. RESULTS: The median age of patients was 63 years (range, 22–92), and 495 patients (42.1%) underwent autologous stem cell transplantation (ASCT). The median log2 EASIX score at diagnosis was 1.1 (IQR 0.3–2.3). Using maximally selected log-rank statistics, the optimal EASIX cutoff value for OS was 1.87 on the log2 scale (95% CI 0.562–0.619, p < 0.001). After median follow-up for 50.0 months (range, 0.3–184.1), the median OS was 58.2 months (95% CI 53.644–62.674). Overall, 372 patients (31.6%) showed high EASIX scores at diagnosis, and had significantly inferior OS compared to those with low EASIX (log2 EASIX ≤1.87) (39.1 months vs. 67.2 months, p < 0.001). In multivariate Cox analysis, high EASIX was significantly associated with poor OS (HR 1.444, 95% CI 1.170–1.780, p = 0.001). In the subgroup analysis of patients who underwent ASCT, patients with high EASIX showed significantly inferior OS compared to those with low EASIX (52.8 months vs. 87.0 months, p < 0.001). In addition, in each group of ISS I, II, and III, high EASIX was associated with significantly inferior OS (ISS 1, 45.2 months vs. 76.0 months, p = 0.001; ISS 2, 42.3 months vs. 66.5 months, p = 0.002; ISS 3, 36.8 months vs. 55.1 months, p = 0.001). CONCLUSION: EASIX score at diagnosis is a simple and strong predictor for OS in patients with newly diagnosed MM. BioMed Central 2020-08-24 /pmc/articles/PMC7446202/ /pubmed/32831058 http://dx.doi.org/10.1186/s12885-020-07317-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Song, Ga-Young
Jung, Sung-Hoon
Kim, Kihyun
Kim, Seok Jin
Yoon, Sang Eun
Lee, Ho Sup
Kim, Mihee
Ahn, Seo-Yeon
Ahn, Jae-Sook
Yang, Deok-Hwan
Kim, Hyeoung-Joon
Lee, Je-Jung
Endothelial activation and stress index (EASIX) is a reliable predictor for overall survival in patients with multiple myeloma
title Endothelial activation and stress index (EASIX) is a reliable predictor for overall survival in patients with multiple myeloma
title_full Endothelial activation and stress index (EASIX) is a reliable predictor for overall survival in patients with multiple myeloma
title_fullStr Endothelial activation and stress index (EASIX) is a reliable predictor for overall survival in patients with multiple myeloma
title_full_unstemmed Endothelial activation and stress index (EASIX) is a reliable predictor for overall survival in patients with multiple myeloma
title_short Endothelial activation and stress index (EASIX) is a reliable predictor for overall survival in patients with multiple myeloma
title_sort endothelial activation and stress index (easix) is a reliable predictor for overall survival in patients with multiple myeloma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446202/
https://www.ncbi.nlm.nih.gov/pubmed/32831058
http://dx.doi.org/10.1186/s12885-020-07317-y
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