Pan-Cancer Analysis of BRCA1 and BRCA2 Genomic Alterations and Their Association With Genomic Instability as Measured by Genome-Wide Loss of Heterozygosity

PURPOSE: BRCA1 or BRCA2 loss of function results in homologous recombination deficiency (HRD), which is targetable by poly (ADP-ribose) polymerase (PARP) inhibitors and other DNA-damaging agents. In cancers associated with germline BRCA1/2 alterations (BRCA1/2-associated cancers: breast, ovarian, pa...

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Detalles Bibliográficos
Autores principales: Sokol, Ethan S., Pavlick, Dean, Khiabanian, Hossein, Frampton, Garrett M., Ross, Jeffrey S., Gregg, Jeffrey P., Lara, Primo N., Oesterreich, Steffi, Agarwal, Neeraj, Necchi, Andrea, Miller, Vincent A., Alexander, Brian, Ali, Siraj M., Ganesan, Shridar, Chung, Jon H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Clinical Oncology 2020
Materias:
Original Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446440/
https://www.ncbi.nlm.nih.gov/pubmed/32903788
http://dx.doi.org/10.1200/PO.19.00345

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