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Relationship between the history of cerebrovascular disease and mortality in COVID-19 patients: A systematic review and meta-analysis
BACKGROUND AND OBJECTIVES: Past history of stroke has been associated with an increased risk of a new ischemic stroke. Several studies have indicated increased prevalence of strokes among coronavirus patients. However, the role of past history of stroke in COVID19 patients is still unclear. The purp...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446719/ https://www.ncbi.nlm.nih.gov/pubmed/32919240 http://dx.doi.org/10.1016/j.clineuro.2020.106183 |
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author | Florez-Perdomo, William Andrés Serrato-Vargas, Sergio Andrés Bosque-Varela, Pilar Moscote-Salazar, Luis Rafael Joaquim, Andrei F. Agrawal, Amit Soto-Angel, Álvaro Ricardo Tovar-Montenegro, Leidy Tatiana |
author_facet | Florez-Perdomo, William Andrés Serrato-Vargas, Sergio Andrés Bosque-Varela, Pilar Moscote-Salazar, Luis Rafael Joaquim, Andrei F. Agrawal, Amit Soto-Angel, Álvaro Ricardo Tovar-Montenegro, Leidy Tatiana |
author_sort | Florez-Perdomo, William Andrés |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: Past history of stroke has been associated with an increased risk of a new ischemic stroke. Several studies have indicated increased prevalence of strokes among coronavirus patients. However, the role of past history of stroke in COVID19 patients is still unclear. The purpose of this systematic review is to evaluate and summarize the level of evidence on past history of stroke in COVID19 patients. METHODS: A systematic review was performed according to the PRISMA guidelines was performed in PubMed, Embase, EBSCO Host, Scopus, Science Direct, Medline, and LILACS. Eligibility criteria: We evaluated studies including patients with diagnosis of COVID 19 and a past history of stroke. Risk of bias: was evaluated with the Newcastle- Ottawa Scale (NOS) and experimental studies were evaluated using the ROBINS-I scale. RESULTS: Seven articles out of the total 213 articles were evaluated and included, involving 3244 patients with SARS VOC 2 Disease (COVID19) of which 198 had a history of cerebrovascular disease. Meta-analysis of the data was performed, observing an increase in mortality in patients with a history of cerebrovascular disease compared to those with different comorbidities or those without underlying pathology (OR 2.78 95 % CI [1.42–5.46] p = 0.007; I(2) = 49 %) showing adequate heterogeneity. The presence of publication bias was evaluated using the Egger test in a funnel plot, showing adequate. Asymmetry, indicating that there is no publication bias; however, due to the low number of included studies, we could not rule out or confirm the presence of bias. CONCLUSIONS: The history of cerebrovascular disease was associated with a 2.78-fold increased risk of mortality compared to patients with other comorbidities or without underlying pathologies. |
format | Online Article Text |
id | pubmed-7446719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74467192020-08-26 Relationship between the history of cerebrovascular disease and mortality in COVID-19 patients: A systematic review and meta-analysis Florez-Perdomo, William Andrés Serrato-Vargas, Sergio Andrés Bosque-Varela, Pilar Moscote-Salazar, Luis Rafael Joaquim, Andrei F. Agrawal, Amit Soto-Angel, Álvaro Ricardo Tovar-Montenegro, Leidy Tatiana Clin Neurol Neurosurg Article BACKGROUND AND OBJECTIVES: Past history of stroke has been associated with an increased risk of a new ischemic stroke. Several studies have indicated increased prevalence of strokes among coronavirus patients. However, the role of past history of stroke in COVID19 patients is still unclear. The purpose of this systematic review is to evaluate and summarize the level of evidence on past history of stroke in COVID19 patients. METHODS: A systematic review was performed according to the PRISMA guidelines was performed in PubMed, Embase, EBSCO Host, Scopus, Science Direct, Medline, and LILACS. Eligibility criteria: We evaluated studies including patients with diagnosis of COVID 19 and a past history of stroke. Risk of bias: was evaluated with the Newcastle- Ottawa Scale (NOS) and experimental studies were evaluated using the ROBINS-I scale. RESULTS: Seven articles out of the total 213 articles were evaluated and included, involving 3244 patients with SARS VOC 2 Disease (COVID19) of which 198 had a history of cerebrovascular disease. Meta-analysis of the data was performed, observing an increase in mortality in patients with a history of cerebrovascular disease compared to those with different comorbidities or those without underlying pathology (OR 2.78 95 % CI [1.42–5.46] p = 0.007; I(2) = 49 %) showing adequate heterogeneity. The presence of publication bias was evaluated using the Egger test in a funnel plot, showing adequate. Asymmetry, indicating that there is no publication bias; however, due to the low number of included studies, we could not rule out or confirm the presence of bias. CONCLUSIONS: The history of cerebrovascular disease was associated with a 2.78-fold increased risk of mortality compared to patients with other comorbidities or without underlying pathologies. Elsevier B.V. 2020-10 2020-08-25 /pmc/articles/PMC7446719/ /pubmed/32919240 http://dx.doi.org/10.1016/j.clineuro.2020.106183 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Florez-Perdomo, William Andrés Serrato-Vargas, Sergio Andrés Bosque-Varela, Pilar Moscote-Salazar, Luis Rafael Joaquim, Andrei F. Agrawal, Amit Soto-Angel, Álvaro Ricardo Tovar-Montenegro, Leidy Tatiana Relationship between the history of cerebrovascular disease and mortality in COVID-19 patients: A systematic review and meta-analysis |
title | Relationship between the history of cerebrovascular disease and mortality in COVID-19 patients: A systematic review and meta-analysis |
title_full | Relationship between the history of cerebrovascular disease and mortality in COVID-19 patients: A systematic review and meta-analysis |
title_fullStr | Relationship between the history of cerebrovascular disease and mortality in COVID-19 patients: A systematic review and meta-analysis |
title_full_unstemmed | Relationship between the history of cerebrovascular disease and mortality in COVID-19 patients: A systematic review and meta-analysis |
title_short | Relationship between the history of cerebrovascular disease and mortality in COVID-19 patients: A systematic review and meta-analysis |
title_sort | relationship between the history of cerebrovascular disease and mortality in covid-19 patients: a systematic review and meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446719/ https://www.ncbi.nlm.nih.gov/pubmed/32919240 http://dx.doi.org/10.1016/j.clineuro.2020.106183 |
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