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Alpha-crystallin mutations alter lens metabolites in mouse models of human cataracts
Cataracts are a major cause of blindness worldwide and commonly occur in individuals over 70 years old. Cataracts can also appear earlier in life due to genetic mutations. The lens proteins, αA- and αB-crystallins, are chaperone proteins that have important roles maintaining protein solubility to pr...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446835/ https://www.ncbi.nlm.nih.gov/pubmed/32833997 http://dx.doi.org/10.1371/journal.pone.0238081 |