Effect of FHA and Prn on Bordetella pertussis colonization of mice is dependent on vaccine type and anatomical site

Bordetella pertussis vaccine escape mutants that lack expression of the pertussis antigen pertactin (Prn) have emerged in vaccinated populations in the last 10–20 years. Additionally, clinical isolates lacking another acellular pertussis (aP) vaccine component, filamentous hemagglutinin (FHA), have...

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Detalles Bibliográficos
Autores principales: Zeddeman, Anne, van Schuppen, Evi, Kok, Kristianne E., van Gent, Marjolein, Heuvelman, Kees J., Bart, Marieke J., van der Heide, Han G. J., Gillard, Joshua, Simonetti, Elles, Eleveld, Marc J., van Opzeeland, Fred J. H., van Selm, Saskia, de Groot, Ronald, de Jonge, Marien I., Mooi, Frits R., Diavatopoulos, Dimitri A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446907/
https://www.ncbi.nlm.nih.gov/pubmed/32822419
http://dx.doi.org/10.1371/journal.pone.0237394

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