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Descriptive Analysis of Patients Living With HIV Affected by COVID-19

COVID-19 disease has spread globally and was declared a pandemic on March 11, 2020, by the World Health Organization. On March 10, the State of Michigan confirmed its first 2 cases of COVID-19, and the number of confirmed cases has reached 47,182 as of May 11, 2020, with 4555 deaths. SETTING: Curren...

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Autores principales: Gudipati, Smitha, Brar, Indira, Murray, Shannon, McKinnon, John E., Yared, Nicholas, Markowitz, Norman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JAIDS Journal of Acquired Immune Deficiency Syndromes 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446990/
https://www.ncbi.nlm.nih.gov/pubmed/32675771
http://dx.doi.org/10.1097/QAI.0000000000002450
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author Gudipati, Smitha
Brar, Indira
Murray, Shannon
McKinnon, John E.
Yared, Nicholas
Markowitz, Norman
author_facet Gudipati, Smitha
Brar, Indira
Murray, Shannon
McKinnon, John E.
Yared, Nicholas
Markowitz, Norman
author_sort Gudipati, Smitha
collection PubMed
description COVID-19 disease has spread globally and was declared a pandemic on March 11, 2020, by the World Health Organization. On March 10, the State of Michigan confirmed its first 2 cases of COVID-19, and the number of confirmed cases has reached 47,182 as of May 11, 2020, with 4555 deaths. SETTING: Currently, little is known if patients living with HIV (PLWH) are at a higher risk of severe COVID-19 or if their antiretrovirals are protective. This study presents epidemiologic and clinical features of COVID-19 infected PLWH in Detroit, Michigan. METHODS: This is a case series that included 14 PLWH with laboratory-confirmed COVID-19 infection who were evaluated at Henry Ford Hospital in Detroit, Michigan, between March 20, 2020, and April 30, 2020. RESULTS: Fourteen PLWH were diagnosed with COVID-19. Twelve patients were men and 2 were women; 13 patients were virally suppressed. Eight patients were hospitalized, and 6 patients were told to self-quarantine at home after their diagnoses. Three patients who were admitted expired during their hospital stay. No patient required bilevel positive airway pressure or nebulizer use in the emergency department, and none developed acute respiratory distress syndrome, pulmonary embolism, deep venous thrombosis, or a cytokine storm while on therapy for COVID-19. CONCLUSION: Although the clinical spectrum of COVID-19 among PLWH cannot be fully ascertained by this report, it adds to the data that suggest that HIV-positive patients with SARS-CoV-2 infection are not at a greater risk of severe disease or death as compared to HIV-negative patients.
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spelling pubmed-74469902020-08-25 Descriptive Analysis of Patients Living With HIV Affected by COVID-19 Gudipati, Smitha Brar, Indira Murray, Shannon McKinnon, John E. Yared, Nicholas Markowitz, Norman J Acquir Immune Defic Syndr Rapid Communication COVID-19 disease has spread globally and was declared a pandemic on March 11, 2020, by the World Health Organization. On March 10, the State of Michigan confirmed its first 2 cases of COVID-19, and the number of confirmed cases has reached 47,182 as of May 11, 2020, with 4555 deaths. SETTING: Currently, little is known if patients living with HIV (PLWH) are at a higher risk of severe COVID-19 or if their antiretrovirals are protective. This study presents epidemiologic and clinical features of COVID-19 infected PLWH in Detroit, Michigan. METHODS: This is a case series that included 14 PLWH with laboratory-confirmed COVID-19 infection who were evaluated at Henry Ford Hospital in Detroit, Michigan, between March 20, 2020, and April 30, 2020. RESULTS: Fourteen PLWH were diagnosed with COVID-19. Twelve patients were men and 2 were women; 13 patients were virally suppressed. Eight patients were hospitalized, and 6 patients were told to self-quarantine at home after their diagnoses. Three patients who were admitted expired during their hospital stay. No patient required bilevel positive airway pressure or nebulizer use in the emergency department, and none developed acute respiratory distress syndrome, pulmonary embolism, deep venous thrombosis, or a cytokine storm while on therapy for COVID-19. CONCLUSION: Although the clinical spectrum of COVID-19 among PLWH cannot be fully ascertained by this report, it adds to the data that suggest that HIV-positive patients with SARS-CoV-2 infection are not at a greater risk of severe disease or death as compared to HIV-negative patients. JAIDS Journal of Acquired Immune Deficiency Syndromes 2020-10-01 2020-07-15 /pmc/articles/PMC7446990/ /pubmed/32675771 http://dx.doi.org/10.1097/QAI.0000000000002450 Text en Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Rapid Communication
Gudipati, Smitha
Brar, Indira
Murray, Shannon
McKinnon, John E.
Yared, Nicholas
Markowitz, Norman
Descriptive Analysis of Patients Living With HIV Affected by COVID-19
title Descriptive Analysis of Patients Living With HIV Affected by COVID-19
title_full Descriptive Analysis of Patients Living With HIV Affected by COVID-19
title_fullStr Descriptive Analysis of Patients Living With HIV Affected by COVID-19
title_full_unstemmed Descriptive Analysis of Patients Living With HIV Affected by COVID-19
title_short Descriptive Analysis of Patients Living With HIV Affected by COVID-19
title_sort descriptive analysis of patients living with hiv affected by covid-19
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446990/
https://www.ncbi.nlm.nih.gov/pubmed/32675771
http://dx.doi.org/10.1097/QAI.0000000000002450
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