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The impact of HIV-1 subtypes on virologic and immunologic treatment outcomes at the Lagos University Teaching Hospital: A longitudinal evaluation
INTRODUCTION: HIV is a highly diverse virus with significant genetic variability which may confer biologic differences that could impact on treatment outcomes. MATERIALS AND METHODS: We studied the association between HIV subtypes and immunologic and virologic outcomes in a longitudinal cohort of 16...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447033/ https://www.ncbi.nlm.nih.gov/pubmed/32841264 http://dx.doi.org/10.1371/journal.pone.0238027 |
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author | Ogbenna, Ann Abiola Meloni, Seema Inzaule, Seth Hamers, Raph L. Sigaloff, Kim Osibogun, Akin Adeyemo, Titilope Adenike Okonkwo, Prosper Samuels, Jay Osi Kanki, Phyllis J. Rinke de Wit, Tobias F. Akanmu, Alani Sulaimon |
author_facet | Ogbenna, Ann Abiola Meloni, Seema Inzaule, Seth Hamers, Raph L. Sigaloff, Kim Osibogun, Akin Adeyemo, Titilope Adenike Okonkwo, Prosper Samuels, Jay Osi Kanki, Phyllis J. Rinke de Wit, Tobias F. Akanmu, Alani Sulaimon |
author_sort | Ogbenna, Ann Abiola |
collection | PubMed |
description | INTRODUCTION: HIV is a highly diverse virus with significant genetic variability which may confer biologic differences that could impact on treatment outcomes. MATERIALS AND METHODS: We studied the association between HIV subtypes and immunologic and virologic outcomes in a longitudinal cohort of 169 patients on combination antiretroviral therapy. Participants were followed up for 5 years. Demographic data, CD4 cell count and viral loads (VL) were extracted from medical records. Whole protease gene and codon 1–300 of the reverse transcriptase gene were sequenced and analysed. RESULTS: Sixty-four percent of participants were females with a median age of 35 years. Twelve different subtypes were observed, the commonest being CRF 02_AG (55.0%) and subtypes G (23.1%). All subtypes showed steady rise in CD4 count and there was no difference in proportion who achieved CD4+ cell count rise of ≥100 cells/μL from baseline within 12 months’ post-initiation of ART, or ≥350 cells/μL at 60 months’ post-initiation. Median time to attaining a rise of ≥350 cells/μL was 24 months (6–48 months). The proportion that achieved undetectable VL at month 6 and 12 post-initiation of ART were comparable across subtypes. At end of 5(th) year, there was no statistical difference in proportion with virologic failure. CONCLUSION: No association between HIV subtypes and immunologic or virologic response to therapy was observed, suggesting that current first-line ART may have similar efficacy across subtype predominating in South-West Nigeria. |
format | Online Article Text |
id | pubmed-7447033 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-74470332020-08-31 The impact of HIV-1 subtypes on virologic and immunologic treatment outcomes at the Lagos University Teaching Hospital: A longitudinal evaluation Ogbenna, Ann Abiola Meloni, Seema Inzaule, Seth Hamers, Raph L. Sigaloff, Kim Osibogun, Akin Adeyemo, Titilope Adenike Okonkwo, Prosper Samuels, Jay Osi Kanki, Phyllis J. Rinke de Wit, Tobias F. Akanmu, Alani Sulaimon PLoS One Research Article INTRODUCTION: HIV is a highly diverse virus with significant genetic variability which may confer biologic differences that could impact on treatment outcomes. MATERIALS AND METHODS: We studied the association between HIV subtypes and immunologic and virologic outcomes in a longitudinal cohort of 169 patients on combination antiretroviral therapy. Participants were followed up for 5 years. Demographic data, CD4 cell count and viral loads (VL) were extracted from medical records. Whole protease gene and codon 1–300 of the reverse transcriptase gene were sequenced and analysed. RESULTS: Sixty-four percent of participants were females with a median age of 35 years. Twelve different subtypes were observed, the commonest being CRF 02_AG (55.0%) and subtypes G (23.1%). All subtypes showed steady rise in CD4 count and there was no difference in proportion who achieved CD4+ cell count rise of ≥100 cells/μL from baseline within 12 months’ post-initiation of ART, or ≥350 cells/μL at 60 months’ post-initiation. Median time to attaining a rise of ≥350 cells/μL was 24 months (6–48 months). The proportion that achieved undetectable VL at month 6 and 12 post-initiation of ART were comparable across subtypes. At end of 5(th) year, there was no statistical difference in proportion with virologic failure. CONCLUSION: No association between HIV subtypes and immunologic or virologic response to therapy was observed, suggesting that current first-line ART may have similar efficacy across subtype predominating in South-West Nigeria. Public Library of Science 2020-08-25 /pmc/articles/PMC7447033/ /pubmed/32841264 http://dx.doi.org/10.1371/journal.pone.0238027 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication. |
spellingShingle | Research Article Ogbenna, Ann Abiola Meloni, Seema Inzaule, Seth Hamers, Raph L. Sigaloff, Kim Osibogun, Akin Adeyemo, Titilope Adenike Okonkwo, Prosper Samuels, Jay Osi Kanki, Phyllis J. Rinke de Wit, Tobias F. Akanmu, Alani Sulaimon The impact of HIV-1 subtypes on virologic and immunologic treatment outcomes at the Lagos University Teaching Hospital: A longitudinal evaluation |
title | The impact of HIV-1 subtypes on virologic and immunologic treatment outcomes at the Lagos University Teaching Hospital: A longitudinal evaluation |
title_full | The impact of HIV-1 subtypes on virologic and immunologic treatment outcomes at the Lagos University Teaching Hospital: A longitudinal evaluation |
title_fullStr | The impact of HIV-1 subtypes on virologic and immunologic treatment outcomes at the Lagos University Teaching Hospital: A longitudinal evaluation |
title_full_unstemmed | The impact of HIV-1 subtypes on virologic and immunologic treatment outcomes at the Lagos University Teaching Hospital: A longitudinal evaluation |
title_short | The impact of HIV-1 subtypes on virologic and immunologic treatment outcomes at the Lagos University Teaching Hospital: A longitudinal evaluation |
title_sort | impact of hiv-1 subtypes on virologic and immunologic treatment outcomes at the lagos university teaching hospital: a longitudinal evaluation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447033/ https://www.ncbi.nlm.nih.gov/pubmed/32841264 http://dx.doi.org/10.1371/journal.pone.0238027 |
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