Cargando…
A Case of Docetaxel-Induced Rhabdomyolysis
Docetaxel is an antimicrotubule agent with activity in a variety of cancers. Its toxicity profile includes myelosuppression, fluid retention/edema, and peripheral neuropathy. It is also associated with myalgias but the frequency and extent of this toxicity are not well described. Here, we present a...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447151/ https://www.ncbi.nlm.nih.gov/pubmed/32855894 http://dx.doi.org/10.7759/cureus.9380 |
_version_ | 1783574247631749120 |
---|---|
author | Thalambedu, Nishanth Atiq, Muhammad Umair Patel, Sheel |
author_facet | Thalambedu, Nishanth Atiq, Muhammad Umair Patel, Sheel |
author_sort | Thalambedu, Nishanth |
collection | PubMed |
description | Docetaxel is an antimicrotubule agent with activity in a variety of cancers. Its toxicity profile includes myelosuppression, fluid retention/edema, and peripheral neuropathy. It is also associated with myalgias but the frequency and extent of this toxicity are not well described. Here, we present a case of a 48-year-old female with breast cancer who developed bilateral proximal leg pain and inability to walk two weeks after the third cycle of docetaxel and cyclophosphamide. Initial workup showed elevated creatinine kinase (CK) levels which trended up to 9000 U/L suggesting rhabdomyolysis. She was treated with IV isotonic fluids without renal complications. Her CK was 1800 U/L at discharge and normalized two weeks post-discharge. To our knowledge, this is one of the few reports of docetaxel-induced rhabdomyolysis. The purpose of this report is to alert physicians of this rare but morbid complication. |
format | Online Article Text |
id | pubmed-7447151 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-74471512020-08-26 A Case of Docetaxel-Induced Rhabdomyolysis Thalambedu, Nishanth Atiq, Muhammad Umair Patel, Sheel Cureus Internal Medicine Docetaxel is an antimicrotubule agent with activity in a variety of cancers. Its toxicity profile includes myelosuppression, fluid retention/edema, and peripheral neuropathy. It is also associated with myalgias but the frequency and extent of this toxicity are not well described. Here, we present a case of a 48-year-old female with breast cancer who developed bilateral proximal leg pain and inability to walk two weeks after the third cycle of docetaxel and cyclophosphamide. Initial workup showed elevated creatinine kinase (CK) levels which trended up to 9000 U/L suggesting rhabdomyolysis. She was treated with IV isotonic fluids without renal complications. Her CK was 1800 U/L at discharge and normalized two weeks post-discharge. To our knowledge, this is one of the few reports of docetaxel-induced rhabdomyolysis. The purpose of this report is to alert physicians of this rare but morbid complication. Cureus 2020-07-25 /pmc/articles/PMC7447151/ /pubmed/32855894 http://dx.doi.org/10.7759/cureus.9380 Text en Copyright © 2020, Thalambedu et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Thalambedu, Nishanth Atiq, Muhammad Umair Patel, Sheel A Case of Docetaxel-Induced Rhabdomyolysis |
title | A Case of Docetaxel-Induced Rhabdomyolysis |
title_full | A Case of Docetaxel-Induced Rhabdomyolysis |
title_fullStr | A Case of Docetaxel-Induced Rhabdomyolysis |
title_full_unstemmed | A Case of Docetaxel-Induced Rhabdomyolysis |
title_short | A Case of Docetaxel-Induced Rhabdomyolysis |
title_sort | case of docetaxel-induced rhabdomyolysis |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447151/ https://www.ncbi.nlm.nih.gov/pubmed/32855894 http://dx.doi.org/10.7759/cureus.9380 |
work_keys_str_mv | AT thalambedunishanth acaseofdocetaxelinducedrhabdomyolysis AT atiqmuhammadumair acaseofdocetaxelinducedrhabdomyolysis AT patelsheel acaseofdocetaxelinducedrhabdomyolysis AT thalambedunishanth caseofdocetaxelinducedrhabdomyolysis AT atiqmuhammadumair caseofdocetaxelinducedrhabdomyolysis AT patelsheel caseofdocetaxelinducedrhabdomyolysis |