Somatic Gain of KRAS Function in the Endothelium Is Sufficient to Cause Vascular Malformations That Require MEK but Not PI3K Signaling

RATIONALE: We previously identified somatic activating mutations in the KRAS (Kirsten rat sarcoma viral oncogene homologue) gene in the endothelium of the majority of human sporadic brain arteriovenous malformations; a disorder characterized by direct connections between arteries and veins. However,...

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Detalles Bibliográficos
Autores principales: Fish, Jason E., Flores Suarez, Carlos Perfecto, Boudreau, Emilie, Herman, Alexander M., Gutierrez, Manuel Cantu, Gustafson, Dakota, DiStefano, Peter V., Cui, Meng, Chen, Zhiqi, De Ruiz, Karen Berman, Schexnayder, Taylor S., Ward, Christopher S., Radovanovic, Ivan, Wythe, Joshua D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447191/
https://www.ncbi.nlm.nih.gov/pubmed/32552404
http://dx.doi.org/10.1161/CIRCRESAHA.119.316500

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