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Sebaceous Gland Carcinoma with Misleading Clinical Appearance: A Case Report of an Eyelid Lesion

Patient: Female, 53-year-old Final Diagnosis: Sebaceous gland carcinoma Symptoms: Mass in right lower lid Medication: — Clinical Procedure: Full-thickness wedge resection with frozen section control Specialty: Oncology • Ophthalmology • Pathology OBJECTIVE: Challenging differential diagnosis BACKGRO...

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Autores principales: Helmi, Hala A., Alsarhani, Waleed, Alkatan, Hind Manaa, Al-Rikabi, Ammar C., Al-Faky, Yasser H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447290/
https://www.ncbi.nlm.nih.gov/pubmed/32788569
http://dx.doi.org/10.12659/AJCR.925134
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author Helmi, Hala A.
Alsarhani, Waleed
Alkatan, Hind Manaa
Al-Rikabi, Ammar C.
Al-Faky, Yasser H.
author_facet Helmi, Hala A.
Alsarhani, Waleed
Alkatan, Hind Manaa
Al-Rikabi, Ammar C.
Al-Faky, Yasser H.
author_sort Helmi, Hala A.
collection PubMed
description Patient: Female, 53-year-old Final Diagnosis: Sebaceous gland carcinoma Symptoms: Mass in right lower lid Medication: — Clinical Procedure: Full-thickness wedge resection with frozen section control Specialty: Oncology • Ophthalmology • Pathology OBJECTIVE: Challenging differential diagnosis BACKGROUND: Sebaceous gland carcinoma (SGC) is a rare malignant lesion that occurs on the eyelids. It is known to mimic other benign or malignant lesions in clinical presentation, such as a chalazion, basal cell carcinoma, and squamous cell carcinoma. The histopathological diagnosis is the mainstay for diagnosis and is often challenging. CASE REPORT: We describe a case of SGC in a 53-year-old woman who presented with a cauliflower-appearing lesion with pearly telangiectatic vessels and raised margins at the lower eyelid margin. Clinically, we suspected a diagnosis of basal cell carcinoma. Upon complete resection of the lesion, the final diagnosis was SGC based on the histopathological features and immunohistochemical staining characteristics of the tissue. CONCLUSIONS: Due to the possibility of SGC presenting similarly to other lesions, it is essential for ophthalmologists to have a high index of suspicion in its diagnosis. The early and accurate diagnosis of such lesions is important for appropriate management to prevent metastasis or recurrence related to advanced tumors.
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spelling pubmed-74472902020-08-31 Sebaceous Gland Carcinoma with Misleading Clinical Appearance: A Case Report of an Eyelid Lesion Helmi, Hala A. Alsarhani, Waleed Alkatan, Hind Manaa Al-Rikabi, Ammar C. Al-Faky, Yasser H. Am J Case Rep Articles Patient: Female, 53-year-old Final Diagnosis: Sebaceous gland carcinoma Symptoms: Mass in right lower lid Medication: — Clinical Procedure: Full-thickness wedge resection with frozen section control Specialty: Oncology • Ophthalmology • Pathology OBJECTIVE: Challenging differential diagnosis BACKGROUND: Sebaceous gland carcinoma (SGC) is a rare malignant lesion that occurs on the eyelids. It is known to mimic other benign or malignant lesions in clinical presentation, such as a chalazion, basal cell carcinoma, and squamous cell carcinoma. The histopathological diagnosis is the mainstay for diagnosis and is often challenging. CASE REPORT: We describe a case of SGC in a 53-year-old woman who presented with a cauliflower-appearing lesion with pearly telangiectatic vessels and raised margins at the lower eyelid margin. Clinically, we suspected a diagnosis of basal cell carcinoma. Upon complete resection of the lesion, the final diagnosis was SGC based on the histopathological features and immunohistochemical staining characteristics of the tissue. CONCLUSIONS: Due to the possibility of SGC presenting similarly to other lesions, it is essential for ophthalmologists to have a high index of suspicion in its diagnosis. The early and accurate diagnosis of such lesions is important for appropriate management to prevent metastasis or recurrence related to advanced tumors. International Scientific Literature, Inc. 2020-08-13 /pmc/articles/PMC7447290/ /pubmed/32788569 http://dx.doi.org/10.12659/AJCR.925134 Text en © Am J Case Rep, 2020 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Articles
Helmi, Hala A.
Alsarhani, Waleed
Alkatan, Hind Manaa
Al-Rikabi, Ammar C.
Al-Faky, Yasser H.
Sebaceous Gland Carcinoma with Misleading Clinical Appearance: A Case Report of an Eyelid Lesion
title Sebaceous Gland Carcinoma with Misleading Clinical Appearance: A Case Report of an Eyelid Lesion
title_full Sebaceous Gland Carcinoma with Misleading Clinical Appearance: A Case Report of an Eyelid Lesion
title_fullStr Sebaceous Gland Carcinoma with Misleading Clinical Appearance: A Case Report of an Eyelid Lesion
title_full_unstemmed Sebaceous Gland Carcinoma with Misleading Clinical Appearance: A Case Report of an Eyelid Lesion
title_short Sebaceous Gland Carcinoma with Misleading Clinical Appearance: A Case Report of an Eyelid Lesion
title_sort sebaceous gland carcinoma with misleading clinical appearance: a case report of an eyelid lesion
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447290/
https://www.ncbi.nlm.nih.gov/pubmed/32788569
http://dx.doi.org/10.12659/AJCR.925134
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