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Association between PTGER4 polymorphisms and inflammatory bowel disease risk in Caucasian: A meta-analysis

BACKGROUND: The results from previous studies on association between prostaglandin E receptor 4 (PTGER4) polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian were conflict. The present study aimed to investigate the genetic association by conducting a meta-analysis. METHODS: Systemat...

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Autores principales: Wu, Peng-Bo, Qian, Rao, Hong, Chai, Guo, Yi-tian, Yu, Yuan-jie, Zhang, Guo, Tan, Shi-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447366/
https://www.ncbi.nlm.nih.gov/pubmed/32846747
http://dx.doi.org/10.1097/MD.0000000000019756
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author Wu, Peng-Bo
Qian, Rao
Hong, Chai
Guo, Yi-tian
Yu, Yuan-jie
Zhang, Guo
Tan, Shi-Yun
author_facet Wu, Peng-Bo
Qian, Rao
Hong, Chai
Guo, Yi-tian
Yu, Yuan-jie
Zhang, Guo
Tan, Shi-Yun
author_sort Wu, Peng-Bo
collection PubMed
description BACKGROUND: The results from previous studies on association between prostaglandin E receptor 4 (PTGER4) polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian were conflict. The present study aimed to investigate the genetic association by conducting a meta-analysis. METHODS: Systematic literature search was conducted through Wiley Online Library, Chinese National Knowledge Infrastructure (CNKI), and PubMed databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to investigate the associations between rs4613763 T/C, 17234657T/G polymorphisms, and IBD risk in Caucasian. RESULTS: Twenty case-control studies consisting of 18,495 Crohn disease (CD) patients and 4203 ulcerative colitis (UC) patients, as well as 26,063 controls were included in this meta-analysis. The rs4613763T/C polymorphism had obvious influence on CD, UC risk in Caucasian. However, rs17234657T/G polymorphism had obvious influence on CD but not UC in Caucasian. CONCLUSION: This meta-analysis suggested that both the rs4613763 T/C, rs17234657T/G polymorphisms had obvious influence on risk of CD in Caucasian. In addition, rs4613763 T/C, polymorphism had obvious influence on risk of UC in Caucasian.
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spelling pubmed-74473662020-09-04 Association between PTGER4 polymorphisms and inflammatory bowel disease risk in Caucasian: A meta-analysis Wu, Peng-Bo Qian, Rao Hong, Chai Guo, Yi-tian Yu, Yuan-jie Zhang, Guo Tan, Shi-Yun Medicine (Baltimore) 4500 BACKGROUND: The results from previous studies on association between prostaglandin E receptor 4 (PTGER4) polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian were conflict. The present study aimed to investigate the genetic association by conducting a meta-analysis. METHODS: Systematic literature search was conducted through Wiley Online Library, Chinese National Knowledge Infrastructure (CNKI), and PubMed databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to investigate the associations between rs4613763 T/C, 17234657T/G polymorphisms, and IBD risk in Caucasian. RESULTS: Twenty case-control studies consisting of 18,495 Crohn disease (CD) patients and 4203 ulcerative colitis (UC) patients, as well as 26,063 controls were included in this meta-analysis. The rs4613763T/C polymorphism had obvious influence on CD, UC risk in Caucasian. However, rs17234657T/G polymorphism had obvious influence on CD but not UC in Caucasian. CONCLUSION: This meta-analysis suggested that both the rs4613763 T/C, rs17234657T/G polymorphisms had obvious influence on risk of CD in Caucasian. In addition, rs4613763 T/C, polymorphism had obvious influence on risk of UC in Caucasian. Lippincott Williams & Wilkins 2020-08-21 /pmc/articles/PMC7447366/ /pubmed/32846747 http://dx.doi.org/10.1097/MD.0000000000019756 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 4500
Wu, Peng-Bo
Qian, Rao
Hong, Chai
Guo, Yi-tian
Yu, Yuan-jie
Zhang, Guo
Tan, Shi-Yun
Association between PTGER4 polymorphisms and inflammatory bowel disease risk in Caucasian: A meta-analysis
title Association between PTGER4 polymorphisms and inflammatory bowel disease risk in Caucasian: A meta-analysis
title_full Association between PTGER4 polymorphisms and inflammatory bowel disease risk in Caucasian: A meta-analysis
title_fullStr Association between PTGER4 polymorphisms and inflammatory bowel disease risk in Caucasian: A meta-analysis
title_full_unstemmed Association between PTGER4 polymorphisms and inflammatory bowel disease risk in Caucasian: A meta-analysis
title_short Association between PTGER4 polymorphisms and inflammatory bowel disease risk in Caucasian: A meta-analysis
title_sort association between ptger4 polymorphisms and inflammatory bowel disease risk in caucasian: a meta-analysis
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447366/
https://www.ncbi.nlm.nih.gov/pubmed/32846747
http://dx.doi.org/10.1097/MD.0000000000019756
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