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Assessment of the risk of musculoskeletal adverse events associated with fluoroquinolone use in children: A meta-analysis

BACKGROUND: The use of fluoroquinolone antibiotics has been restricted in children because of their potential to cause adverse musculoskeletal events. This study was performed to systematically evaluate whether there is a difference between fluoroquinolone and non-fluoroquinolone antibiotics in term...

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Autores principales: Wang, Ji-gan, Cui, Hai-Rong, Hu, Yi-sen, Tang, Hua-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447478/
https://www.ncbi.nlm.nih.gov/pubmed/32846837
http://dx.doi.org/10.1097/MD.0000000000021860
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author Wang, Ji-gan
Cui, Hai-Rong
Hu, Yi-sen
Tang, Hua-Bo
author_facet Wang, Ji-gan
Cui, Hai-Rong
Hu, Yi-sen
Tang, Hua-Bo
author_sort Wang, Ji-gan
collection PubMed
description BACKGROUND: The use of fluoroquinolone antibiotics has been restricted in children because of their potential to cause adverse musculoskeletal events. This study was performed to systematically evaluate whether there is a difference between fluoroquinolone and non-fluoroquinolone antibiotics in terms of their associated risk of adverse musculoskeletal events in children. METHODS: Cochrane Library, Embase, and PubMed databases were used to retrieve studies related to fluoroquinolone and non-fluoroquinolone-induced musculoskeletal adverse events in children. A meta-analysis was performed using Stata 11. RESULTS: A total of 10 studies were included in the analysis. The combined results showed that there was no statistical difference between fluoroquinolone and non-fluoroquinolone groups in terms of musculoskeletal adverse events in children (risk ratio = 1.145, 95% confidence interval = 0.974 – 1.345, P = .101). Subgroup analysis was performed using a random-effects model. Here, the effects on the trovafloxacin and levofloxacin groups were significantly different from that of the control group. However, musculoskeletal adverse events due to either drug was not reported after long-term follow-up. CONCLUSIONS: The results showed that fluoroquinolone and non-fluoroquinolone antibiotics were not different in terms of their ability to cause musculoskeletal adverse events in children. For this reason, fluoroquinolone antibiotics can be used in children as appropriate. PROSPERO REGISTRATION NUMBER: CRD42019133900
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spelling pubmed-74474782020-09-04 Assessment of the risk of musculoskeletal adverse events associated with fluoroquinolone use in children: A meta-analysis Wang, Ji-gan Cui, Hai-Rong Hu, Yi-sen Tang, Hua-Bo Medicine (Baltimore) 6200 BACKGROUND: The use of fluoroquinolone antibiotics has been restricted in children because of their potential to cause adverse musculoskeletal events. This study was performed to systematically evaluate whether there is a difference between fluoroquinolone and non-fluoroquinolone antibiotics in terms of their associated risk of adverse musculoskeletal events in children. METHODS: Cochrane Library, Embase, and PubMed databases were used to retrieve studies related to fluoroquinolone and non-fluoroquinolone-induced musculoskeletal adverse events in children. A meta-analysis was performed using Stata 11. RESULTS: A total of 10 studies were included in the analysis. The combined results showed that there was no statistical difference between fluoroquinolone and non-fluoroquinolone groups in terms of musculoskeletal adverse events in children (risk ratio = 1.145, 95% confidence interval = 0.974 – 1.345, P = .101). Subgroup analysis was performed using a random-effects model. Here, the effects on the trovafloxacin and levofloxacin groups were significantly different from that of the control group. However, musculoskeletal adverse events due to either drug was not reported after long-term follow-up. CONCLUSIONS: The results showed that fluoroquinolone and non-fluoroquinolone antibiotics were not different in terms of their ability to cause musculoskeletal adverse events in children. For this reason, fluoroquinolone antibiotics can be used in children as appropriate. PROSPERO REGISTRATION NUMBER: CRD42019133900 Lippincott Williams & Wilkins 2020-08-21 /pmc/articles/PMC7447478/ /pubmed/32846837 http://dx.doi.org/10.1097/MD.0000000000021860 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 6200
Wang, Ji-gan
Cui, Hai-Rong
Hu, Yi-sen
Tang, Hua-Bo
Assessment of the risk of musculoskeletal adverse events associated with fluoroquinolone use in children: A meta-analysis
title Assessment of the risk of musculoskeletal adverse events associated with fluoroquinolone use in children: A meta-analysis
title_full Assessment of the risk of musculoskeletal adverse events associated with fluoroquinolone use in children: A meta-analysis
title_fullStr Assessment of the risk of musculoskeletal adverse events associated with fluoroquinolone use in children: A meta-analysis
title_full_unstemmed Assessment of the risk of musculoskeletal adverse events associated with fluoroquinolone use in children: A meta-analysis
title_short Assessment of the risk of musculoskeletal adverse events associated with fluoroquinolone use in children: A meta-analysis
title_sort assessment of the risk of musculoskeletal adverse events associated with fluoroquinolone use in children: a meta-analysis
topic 6200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447478/
https://www.ncbi.nlm.nih.gov/pubmed/32846837
http://dx.doi.org/10.1097/MD.0000000000021860
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