Course of matrix metalloproteinase‐1 and pulmonary oxygenation in acute respiratory distress syndrome caused by oral ingestion of large doses of oxadiazon/butachlor emulsion: a case report

BACKGROUND: We treated a patient who developed acute respiratory distress syndrome following ingestion of oxadiazon/butachlor emulsion. In this case, we continuously measured matrix metalloproteinase‐1 level, an enzyme that reduces the extracellular matrix in the lungs, and tissue inhibitors of metalloproteinase‐1. CASE PRESENTATION: A 50‐year‐old woman attempted suicide by ingesting approximately 300 mL of oxadiazon/butachlor emulsion. Respiratory disorders were observed upon admission, therefore tracheal intubation was performed, followed by artificial respiratory management (ventilator support). After that, her condition became complicated by acute respiratory distress syndrome, but it improved with intensive care management. Matrix metalloproteinase‐1 level showed a course opposite to the partial pressure of arterial oxygen/percentage of inspired oxygen ratio, whereas the matrix metalloproteinase‐1/tissue inhibitors of metalloproteinase‐1 ratio changed in parallel with the partial pressure of arterial oxygen/percentage of inspired oxygen ratio. CONCLUSION: The relationship between matrix metalloproteinase‐1 and tissue inhibitors of metalloproteinase‐1 was presumed to be important for the development of acute respiratory distress syndrome.