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Impact of fecal short‐chain fatty acids on prognosis in critically ill patients

AIM: This study aimed to evaluate the relationship between fecal organic acids and mortality in critically ill patients. METHODS: This retrospective study included 128 patients who fulfilled the criteria of systemic inflammatory response syndrome and had a serum C‐reactive protein level of greater t...

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Autores principales: Nakahori, Yasutaka, Shimizu, Kentaro, Ogura, Hiroshi, Asahara, Takashi, Osuka, Akinori, Yamano, Shuhei, Tasaki, Osamu, Kuwagata, Yasuyuki, Shimazu, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447560/
https://www.ncbi.nlm.nih.gov/pubmed/32864147
http://dx.doi.org/10.1002/ams2.558
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author Nakahori, Yasutaka
Shimizu, Kentaro
Ogura, Hiroshi
Asahara, Takashi
Osuka, Akinori
Yamano, Shuhei
Tasaki, Osamu
Kuwagata, Yasuyuki
Shimazu, Takeshi
author_facet Nakahori, Yasutaka
Shimizu, Kentaro
Ogura, Hiroshi
Asahara, Takashi
Osuka, Akinori
Yamano, Shuhei
Tasaki, Osamu
Kuwagata, Yasuyuki
Shimazu, Takeshi
author_sort Nakahori, Yasutaka
collection PubMed
description AIM: This study aimed to evaluate the relationship between fecal organic acids and mortality in critically ill patients. METHODS: This retrospective study included 128 patients who fulfilled the criteria of systemic inflammatory response syndrome and had a serum C‐reactive protein level of greater than 10 mg/dL. Patients were treated in the intensive care unit for more than 2 days. Patients were divided into two groups: survivors and non‐survivors. We measured and compared eight kinds of fecal organic acids between the two groups. We focused on the minimum and maximum value of each fecal organic acid and evaluated prognostic factors by using classification and regression tree (CART) and multivariate logistic regression analyses. RESULTS: We included 90 patients as survivors and 38 as non‐survivors. The CART analysis revealed that the dominant factors for mortality were the minimum values of propionate and acetate and the maximum values of lactate and formic acid. In the evaluation of the minimum values of fecal organic acids, propionate was significantly associated with increased mortality (odds ratio, 0.11 [95% confidence interval, 0.024–0.51]; P = 0.005), acetate (0.047 [0.005–0.49]; P = 0.01), and age (1.048 [1.015–1.083]; P = 0.004). In the evaluation of the maximum values, lactate was significantly associated with increased mortality (5.21 [2.024–13.42], P = 0.001) and age (1.050 [1.017–1.084]; P = 0.003). CONCLUSION: An altered balance of fecal organic acids was significantly associated with mortality in critically ill patients.
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spelling pubmed-74475602020-08-28 Impact of fecal short‐chain fatty acids on prognosis in critically ill patients Nakahori, Yasutaka Shimizu, Kentaro Ogura, Hiroshi Asahara, Takashi Osuka, Akinori Yamano, Shuhei Tasaki, Osamu Kuwagata, Yasuyuki Shimazu, Takeshi Acute Med Surg Original Articles AIM: This study aimed to evaluate the relationship between fecal organic acids and mortality in critically ill patients. METHODS: This retrospective study included 128 patients who fulfilled the criteria of systemic inflammatory response syndrome and had a serum C‐reactive protein level of greater than 10 mg/dL. Patients were treated in the intensive care unit for more than 2 days. Patients were divided into two groups: survivors and non‐survivors. We measured and compared eight kinds of fecal organic acids between the two groups. We focused on the minimum and maximum value of each fecal organic acid and evaluated prognostic factors by using classification and regression tree (CART) and multivariate logistic regression analyses. RESULTS: We included 90 patients as survivors and 38 as non‐survivors. The CART analysis revealed that the dominant factors for mortality were the minimum values of propionate and acetate and the maximum values of lactate and formic acid. In the evaluation of the minimum values of fecal organic acids, propionate was significantly associated with increased mortality (odds ratio, 0.11 [95% confidence interval, 0.024–0.51]; P = 0.005), acetate (0.047 [0.005–0.49]; P = 0.01), and age (1.048 [1.015–1.083]; P = 0.004). In the evaluation of the maximum values, lactate was significantly associated with increased mortality (5.21 [2.024–13.42], P = 0.001) and age (1.050 [1.017–1.084]; P = 0.003). CONCLUSION: An altered balance of fecal organic acids was significantly associated with mortality in critically ill patients. John Wiley and Sons Inc. 2020-08-25 /pmc/articles/PMC7447560/ /pubmed/32864147 http://dx.doi.org/10.1002/ams2.558 Text en © 2020 The Authors. Acute Medicine & Surgery published by John Wiley & Sons Australia, Ltd on behalf of Japanese Association for Acute Medicine This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Nakahori, Yasutaka
Shimizu, Kentaro
Ogura, Hiroshi
Asahara, Takashi
Osuka, Akinori
Yamano, Shuhei
Tasaki, Osamu
Kuwagata, Yasuyuki
Shimazu, Takeshi
Impact of fecal short‐chain fatty acids on prognosis in critically ill patients
title Impact of fecal short‐chain fatty acids on prognosis in critically ill patients
title_full Impact of fecal short‐chain fatty acids on prognosis in critically ill patients
title_fullStr Impact of fecal short‐chain fatty acids on prognosis in critically ill patients
title_full_unstemmed Impact of fecal short‐chain fatty acids on prognosis in critically ill patients
title_short Impact of fecal short‐chain fatty acids on prognosis in critically ill patients
title_sort impact of fecal short‐chain fatty acids on prognosis in critically ill patients
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447560/
https://www.ncbi.nlm.nih.gov/pubmed/32864147
http://dx.doi.org/10.1002/ams2.558
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